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주간과다졸림의 원인이 되는 수면장애에서 약물 사용: 최신 진료지침과 국내 현황

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dc.contributor.author김경민-
dc.contributor.author김승우-
dc.date.accessioned2026-01-06T00:45:00Z-
dc.date.available2026-01-06T00:45:00Z-
dc.date.issued2025-11-
dc.identifier.issn1225-7044-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/209759-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.publisher대한신경과학회-
dc.relation.isPartOfJournal of the Korean Neurological Association(대한신경과학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHSleepiness-
dc.subject.MESHHypersomnolence disorders-
dc.subject.MESHSleep apnea-
dc.subject.MESHobstructive-
dc.subject.MESHSleep disorders-
dc.subject.MESHcircadian rhythm-
dc.subject.MESHReal-world evidence-
dc.subject.MESHWakefulness-promoting agents-
dc.title주간과다졸림의 원인이 되는 수면장애에서 약물 사용: 최신 진료지침과 국내 현황-
dc.title.alternativePharmacotherapy for Excessive Daytime Sleepiness in Sleep Disorders: Comparative Guidelines and the Clinical Landscape in South Korea-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthor최윤호-
dc.contributor.googleauthor김경민-
dc.contributor.googleauthor김병수-
dc.contributor.googleauthor김희진-
dc.contributor.googleauthor김승우-
dc.contributor.googleauthor백경원-
dc.contributor.googleauthor석진명-
dc.contributor.googleauthor선우준상-
dc.contributor.googleauthor송인욱-
dc.contributor.googleauthor우호걸-
dc.contributor.googleauthor이익성-
dc.contributor.googleauthor정진만-
dc.contributor.googleauthor최교민-
dc.contributor.googleauthor양광익-
dc.contributor.googleauthor대한신경과학회 진료지침위원회-
dc.identifier.doi10.17340/jkna.2025.0045-
dc.contributor.localIdA05748-
dc.contributor.localIdA04901-
dc.relation.journalcodeJ01836-
dc.subject.keywordExcessive daytime sleepiness (EDS) is a prevalent symptom that significantly impairs quality of life and poses substantial public health risks. A precise differential diagnosis is crucial, beginning with common causes such as insufficient sleep, circadian rhythm sleep-wake disorders, and sleep-disrupting conditions like obstructive sleep apnea (OSA), before proceeding to the central disorders of hypersomnolence. This review provides a comprehensive overview of pharmacological agents for the treatment of EDS, including modafinil/armodafinil, pitolisant, solriamfetol, sodium oxybate, methylphenidate, and amphetamines. We provide a comparative analysis of clinical practice guidelines and regulatory status in the United States, Europe, and Japan, highlighting differences in first-line recommendations, approved indications, and therapeutic algorithms for conditions such as narcolepsy, idiopathic hypersomnia, residual EDS in OSA, and shift-work sleep disorder. Furthermore, we address the unique clinical landscape in South Korea, where significant discrepancies exist between drug approvals and reimbursement criteria. Limited health insurance coverage, the unavailability of key medications such as solriamfetol and sodium oxybate, and the recent withdrawal of pitolisant from the market severely restrict therapeutic options. These challenges create a substantial unmet need, particularly for pediatric patients and those with OSA-related residual sleepiness or shift work disorder. This review highlights the pressing need to improve patient access to evidence based treatments in South Korea and to generate domestic real-world data to support clinical decision-making and health policy revision.-
dc.contributor.alternativeNameKim, Kyung Min-
dc.contributor.affiliatedAuthor김경민-
dc.contributor.affiliatedAuthor김승우-
dc.citation.volume43-
dc.citation.number4-
dc.citation.startPage233-
dc.citation.endPage244-
dc.identifier.bibliographicCitationJournal of the Korean Neurological Association (대한신경과학회지), Vol.43(4) : 233-244, 2025-11-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
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