YUHSpace

BROWSE

Export
6 12

Cited 0 times in

Cited 0 times in

항발작약물의 발작 외 신경계 질환 사용

DC Field Value Language
dc.contributor.author김경민-
dc.contributor.author김승우-
dc.date.accessioned2026-01-06T00:44:49Z-
dc.date.available2026-01-06T00:44:49Z-
dc.date.issued2025-11-
dc.identifier.issn1225-7044-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/209757-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.publisher대한신경과학회-
dc.relation.isPartOfJournal of the Korean Neurological Association(대한신경과학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAntiseizure medications-
dc.subject.MESHMigraine disorders-
dc.subject.MESHNeuralgia-
dc.subject.MESHRestless legs syndrome-
dc.subject.MESHBipolar disorder-
dc.title항발작약물의 발작 외 신경계 질환 사용-
dc.title.alternativeUse of Antiseizure Medications in Neurological Disorders Beyond Epilepsy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthor김경민-
dc.contributor.googleauthor김병수-
dc.contributor.googleauthor김희진-
dc.contributor.googleauthor김승우-
dc.contributor.googleauthor백경원-
dc.contributor.googleauthor석진명-
dc.contributor.googleauthor선우준상-
dc.contributor.googleauthor송인욱-
dc.contributor.googleauthor우호걸-
dc.contributor.googleauthor이익성-
dc.contributor.googleauthor정진만-
dc.contributor.googleauthor최교민-
dc.contributor.googleauthor최윤호-
dc.contributor.googleauthor양광익-
dc.identifier.doi10.17340/jkna.2025.0043-
dc.contributor.localIdA05748-
dc.contributor.localIdA04901-
dc.relation.journalcodeJ01836-
dc.subject.keywordAntiseizure medications (ASMs), originally developed for epilepsy, are increasingly used across non-epileptic neurological disorders. They modulate excitatory -inhibitory balance, nociceptive sensitization, neuroplasticity, trigeminal activation, and sleep- wake regulation through actions on voltage-gated ion channels, GABAergic and glutamatergic transmission, and synaptic vesicle proteins. These mechanisms underlie their broader therapeutic potential. In migraine, topiramate and valproate reduce attack frequency and chronification risk, and remain first- or second-line preventive options in current guidelines. In neuropathic pain, gabapentin and pregabalin alleviate peripheral and central sensitization and are effective in diabetic neuropathy, postherpetic neuralgia, and trigeminal neuralgia, improving pain and sleep though requiring cautious use in older or opioid-treated patients. ASMs enhance slow-wave sleep and are now preferred first-line therapy for restless legs syndrome, offering lower augmentation risk than dopamine agonists. In movement disorders, primidone and topiramate reduce tremor severity in essential tremor, while carbamazepine and oxcarbazepine effectively prevent attacks in paroxysmal kinesigenic dyskinesia. Lamotrigine, valproate, and carbamazepine are established mood stabilizers in bipolar disorder, while gabapentinoids may be cautiously used as adjuncts in anxiety disorders or post-traumatic stress disorder. While ASMs provide valuable alternatives for refractory or intolerant patients, safety concerns, including cognitive impairment, respiratory depression, and severe skin reactions, necessitate individualized selection, monitoring, and informed consent. Future research should clarify their long-term safety and enable biomarker-guided, personalized use beyond epilepsy.-
dc.contributor.alternativeNameKim, Kyung Min-
dc.contributor.affiliatedAuthor김경민-
dc.contributor.affiliatedAuthor김승우-
dc.citation.volume43-
dc.citation.number4-
dc.citation.startPage245-
dc.citation.endPage252-
dc.identifier.bibliographicCitationJournal of the Korean Neurological Association (대한신경과학회지), Vol.43(4) : 245-252, 2025-11-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Show simple item record Find it @ YMLIB

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

  • License
    sherpa_romeo
    sherpa_juliet

OAK

DSpace Software Copyright © 2002-2017 Duraspace Yonsei University Medical Library All right Reserves. / TEL:02-2228-2915 /
YUHSpace는 국립중앙도서관 OAK 보급사업으로 구축되었습니다.

Browse

Links