Orofacial pain symptoms as potential risk factor for cardiovascular diseases: A cohort study

Abstract

ObjectivesTo investigate the longitudinal impact of orofacial pain symptoms on cardiovascular diseases (CVDs) risk.MethodsData from 692,980 Korean individuals were analyzed and categorized by the presence or absence of orofacial pain symptoms. Multivariate Cox proportional hazard regression analyses were conducted to calculate hazard ratios (HRs) of orofacial pain for the incidence of major adverse cardiovascular events (MACE).ResultsA total of 47,824 (7.41%) participants reported orofacial pain symptoms, which were associated with increased MACE risks. However, some cases may have referred to cardiac pain rather than primary orofacial pain.ConclusionsOrofacial pain may independently increase the long-term risk of CVD.