Spin in randomized controlled trials of pharmacology in COVID-19: A systematic review

Abstract

Spin, defined as the misrepresentation of the results of a study, could negate the validity of scientific findings. To explore the manifestation of spin, and identify the factors affecting spin in COVID-19 RCTs, a systematic review was performed from PubMed/Medline, National Institutes of Health, EMBASE, Cochrane, and Web of Science. RCTs on pharmacotherapy for COVID-19 with nonsignificant primary outcomes published in 2020 were included. 21 abstracts (33.9%) and 28 main texts (45.2%) were found to contain spin in at least one section. In the conclusion section, other spin strategies beautifying their findings that were not included in the abstract were found in the main texts. More factors influencing the level of spin were found in abstracts than in the main texts, but most of the levels of spin in abstracts were comparable to those in the main texts. Although common factors that affected the manifestation of spin in the main texts and abstracts were the sample size and type of journal, further research to determine multicollinearity between significant factors and the manifestation of spin is required.