Efficacy and Safety of Poly-D,L-lactic Acid Delivered via a Transdermal Needle-free Microjet System for Enlarged Facial Pores

Abstract

Enlarged facial pores are a common cosmetic concern influenced by factors such as age, genetics, and sebum production. Traditional treatments such as topical retinoids, chemical peels, and laser therapies often yield variable results and may involve discomfort or multiple sessions. We report the case of a 41-year-old Korean woman treated for visibly enlarged pores using poly-D,L-lactic acid delivered via a needle-free microjet system. This system uses advanced electromagnetic technology to create high-pressure microjets that penetrate the skin's outer layers, delivering therapeutic agents directly into the dermis. The patient underwent 5 monthly sessions, with significant improvements in pore size and skin texture observed within 4 weeks posttreatment. Clinical assessments showed a reduction in pore size from a baseline score of 6 to 3, sustained through 12 weeks posttreatment. The patient expressed satisfaction with the outcomes, reporting firmer, smoother skin with no adverse effects. Poly-D,L-lactic acid delivered via a microjet system was an effective, noninvasive treatment for enlarged facial pores in the treated patient. Further studies are needed to validate these findings and compare this approach with established therapies.