Breaking data silos: incorporating the DICOM imaging standard into the OMOP CDM to enable multimodal research

Abstract

Objective This work incorporates the Digital Imaging Communications in Medicine (DICOM) Standard into the Observational Medical Outcomes Partnership Common Data Model (OMOP CDM) to standardize and accurately represent imaging studies, such as acquisition parameters, in multimodal research studies.Materials and Methods DICOM is the internationally adopted standard that defines entities and relationships for biomedical imaging data used for clinical imaging studies. Most of the complexity in the DICOM data structure centers around the metadata. This metadata contains information about the patient and the modality acquisition parameters. We parsed the DICOM vocabularies in Parts 3, 6, and 16 to obtain structured metadata definitions and added these as custom concepts in the OMOP CDM vocabulary. To validate our pipeline, we harvested and transformed DICOM metadata from magnetic resonance images in the Alzheimer's Disease Neuroimaging Initiative (ADNI) study.Results We extracted and added 5183 attributes and 3628 coded values from the DICOM standard as custom concepts to the OMOP CDM vocabulary. We ingested 545 ADNI imaging studies containing 4756 series and harvested 691 224 metadata values. They were filtered, transformed, and loaded in the OMOP CDM imaging extension using the OMOP concepts for the DICOM attributes and values.Discussion This work is adaptable to clinical DICOM data. Future work will validate scalability and incorporate outcomes from automated analysis to provide a complete characterization research study within the OMOP framework.Conclusion The incorporation of medical imaging into clinical observational studies has been a barrier to multi model research. This work demonstrates detailed phenotypes and paves the way for observational multimodal research.