Associations of accelerometer-derived moderate-to-vigorous physical activity and atrioventricular block in a healthy elderly population

Abstract

BACKGROUND There is limited information on protective factors related to atrioventricular (AV) block. OBJECTIVE This study examines the association between accelerometer-derived moderate-to-vigorous physical activity (MVPA) and AV block in healthy elderly individuals. METHODS A total of 23,590 UK Biobank participants >= 60 years of age involved in a wrist-worn accelerometer study with no history of hypertension, diabetes mellitus, dyslipidemia, and coronary heart disease were analyzed. The associations of MVPA with primary (second- or third-degree AV block) and secondary outcome (third-degree AV block, pacemaker implantation) were evaluated by Cox regression analysis. The associations of MVPA with electrocardiogram parameters were evaluated by linear regression analysis. RESULTS The mean age was 63.8 6 2.8 years, and 57.4% were women. During the median follow-up period of 6.1 years, 115 primary outcome events occurred. Compared with quintile 1 (<89 min/week), those in quintile 4 (280-449 min/week) had a 63% lower incidence of primary outcome (hazard ratio [HR] 0.37, 95% confidence interval [CI] 0.19-0.73, P = .004); however, the result was attenuated in quintile 5. This pattern was consistently observed in the relationship between MVPA and third-degree AV block (quintile 4 vs quintile 1: HR 0.29, 95% CI 0.11-0.74, P = .010) and pacemaker implantation. MVPA per 150 minutes per week increase was independently negatively associated with normalized PQ interval (msec) (b: -2.13, 95% CONCLUSION In the healthy elderly population, MVPA was associated with a lower risk of second- or third-degree AV block, which correlates with the reduction of normalized PQ interval. However, excessive MVPA attenuated the results.