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Comparison of High-Dose versus Low-Dose Paclitaxel Drug-Coated Balloons for Native Femoropopliteal Artery Disease: An Analysis of the K-VIS ELLA Registry

DC Field Value Language
dc.contributor.author고영국-
dc.contributor.author김병극-
dc.contributor.author김중선-
dc.contributor.author민필기-
dc.contributor.author안철민-
dc.contributor.author이상협-
dc.contributor.author이승준-
dc.contributor.author최동훈-
dc.contributor.author홍명기-
dc.contributor.author홍성진-
dc.date.accessioned2025-10-15T02:02:18Z-
dc.date.available2025-10-15T02:02:18Z-
dc.date.issued2025-07-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/207552-
dc.description.abstractPeripheral artery disease ; balloon angioplasty ; paclitaxel ; popliteal artery-
dc.description.statementOfResponsibilityT202506287.pdf-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESH0-
dc.titleComparison of High-Dose versus Low-Dose Paclitaxel Drug-Coated Balloons for Native Femoropopliteal Artery Disease: An Analysis of the K-VIS ELLA Registry-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorJaeoh Lee-
dc.contributor.googleauthorYoung-Guk Ko-
dc.contributor.googleauthorSeung-Jun Lee-
dc.contributor.googleauthorSang-Hyup Lee-
dc.contributor.googleauthorYong-Joon Lee-
dc.contributor.googleauthorSung-Jin Hong-
dc.contributor.googleauthorChul-Min Ahn-
dc.contributor.googleauthorJung-Sun Kim-
dc.contributor.googleauthorByeong-Keuk Kim-
dc.contributor.googleauthorMyeong-Ki Hong-
dc.contributor.googleauthorCheol Woong Yu-
dc.contributor.googleauthorJae-Hwan Lee-
dc.contributor.googleauthorSeung-Whan Lee-
dc.contributor.googleauthorYoung Jin Youn-
dc.contributor.googleauthorJong Kwan Park-
dc.contributor.googleauthorChang-Hwan Yoon-
dc.contributor.googleauthorSeung Woon Rha-
dc.contributor.googleauthorPil-Ki Min-
dc.contributor.googleauthorSeung-Hyuk Choi-
dc.contributor.googleauthorIn-Ho Chae-
dc.contributor.googleauthorDonghoon Choi-
dc.contributor.googleauthorK-VIS ELLA investigators-
dc.identifier.doiPurpose: Drug-coated balloons (DCBs) have demonstrated favorable outcomes in the treatment of femoropopliteal artery (FPA) disease. A variety of DCBs are currently available, with differing doses of antiproliferative agents and types of excipients. The objective of this study was to compare the efficacy and safety of high-dose versus low-dose paclitaxel DCBs for the treatment of FPA disease. Materials and methods: We analyzed data from the multicenter the Korean Vascular Intervention Society Endovascular Therapy in Lower Limb Artery Diseases (K-VIS ELLA) registry, focusing on patients treated with a high-dose paclitaxel DCB (IN.PACT™) or low-dose paclitaxel DCB (Lutonix™ or Ranger™) for native vessel FPA disease. We used inverse probability of treatment weighting to adjust for confounding factors and conducted subgroup analyses based on lesion characteristics. Results: Among 820 target limbs, 626 were treated with a high-dose paclitaxel DCB, and 194 were treated with a low-dose paclitaxel DCB. At 12 months, there were no significant differences in rates of freedom from clinically driven target lesion revascularization (TLR; 91.7% vs. 89.4%, log-rank p=0.35), major adverse limb event (MALE; 91.4% vs. 89.0%, log-rank p=0.31), or all-cause mortality (93.1% vs. 93.8%, log-rank p=0.79) between high-dose and low-dose groups. On multivariable analysis, the presence of chronic heart failure and chronic kidney disease were the only independent predictors of clinically driven TLR after DCB treatment. Conclusion: In this multicenter cohort study of patients with complex FPA disease, there were no significant differences between high-dose DCB and low-dose DCB with respect to freedom from clinically driven TLR, MALE, or all-cause mortality at 12-month follow-up.-
dc.contributor.localIdA00127-
dc.contributor.localIdA00493-
dc.contributor.localIdA00961-
dc.contributor.localIdA01412-
dc.contributor.localIdA02269-
dc.contributor.localIdA06152-
dc.contributor.localIdA02927-
dc.contributor.localIdA04053-
dc.contributor.localIdA04391-
dc.contributor.localIdA04403-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid40551590-
dc.subject.keywordAged-
dc.subject.keywordAged, 80 and over-
dc.subject.keywordFemale-
dc.subject.keywordFemoral Artery* / pathology-
dc.subject.keywordFemoral Artery* / surgery-
dc.subject.keywordHumans-
dc.subject.keywordMale-
dc.subject.keywordMiddle Aged-
dc.subject.keywordPaclitaxel* / administration & dosage-
dc.subject.keywordPaclitaxel* / therapeutic use-
dc.subject.keywordPeripheral Arterial Disease* / drug therapy-
dc.subject.keywordPopliteal Artery* / drug effects-
dc.subject.keywordPopliteal Artery* / pathology-
dc.subject.keywordPopliteal Artery* / surgery-
dc.subject.keywordRegistries-
dc.subject.keywordTreatment Outcome-
dc.contributor.alternativeNameKo, Young Guk-
dc.contributor.affiliatedAuthor고영국-
dc.contributor.affiliatedAuthor김병극-
dc.contributor.affiliatedAuthor김중선-
dc.contributor.affiliatedAuthor민필기-
dc.contributor.affiliatedAuthor안철민-
dc.contributor.affiliatedAuthor이상협-
dc.contributor.affiliatedAuthor이승준-
dc.contributor.affiliatedAuthor최동훈-
dc.contributor.affiliatedAuthor홍명기-
dc.contributor.affiliatedAuthor홍성진-
dc.citation.volume66-
dc.citation.number7-
dc.citation.startPage412-
dc.citation.endPage420-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.66(7) : 412-420, 2025-07-
dc.identifier.articleno10.3349/ymj.2024.0166-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
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