YUHSpace

BROWSE

Export
0 1

Cited 0 times in

Cited 0 times in

Pericoronary Adipose Tissue Attenuation in Patients with Future Acute Coronary Syndromes: The ICONIC Study

DC Field Value Language
dc.contributor.author장혁재-
dc.date.accessioned2025-10-15T02:00:07Z-
dc.date.available2025-10-15T02:00:07Z-
dc.date.issued2025-06-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/207540-
dc.description.abstractAcute Coronary Syndrome ; CT-Angiography ; Cardiovascular Risk ; Coronary Arteries ; ICONIC Study ; Inflammation ; Noncalcified Plaque ; Pericoronary Adipose Tissue Attenuation-
dc.description.statementOfResponsibilityhttps://pubs.rsna.org/doi/10.1148/ryct.240200-
dc.languageEnglish-
dc.publisherRadiological Society of North America, Inc-
dc.relation.isPartOfRADIOLOGY-CARDIOTHORACIC IMAGING-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESH1-
dc.titlePericoronary Adipose Tissue Attenuation in Patients with Future Acute Coronary Syndromes: The ICONIC Study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorAlan C Kwan-
dc.contributor.googleauthorEvangelos Tzolos-
dc.contributor.googleauthorEyal Klein-
dc.contributor.googleauthorDonghee Han-
dc.contributor.googleauthorAndrew Lin-
dc.contributor.googleauthorKeiichiro Kuronuma-
dc.contributor.googleauthorBilly Chen-
dc.contributor.googleauthorGuadalupe Flores Tomasino-
dc.contributor.googleauthorHeidi Gransar-
dc.contributor.googleauthorPiotr J Slomka-
dc.contributor.googleauthorSusan Cheng-
dc.contributor.googleauthorCatherine Gebhard-
dc.contributor.googleauthorPhilipp Kaufmann-
dc.contributor.googleauthorJeroen J Bax-
dc.contributor.googleauthorFilippo Cademartiri-
dc.contributor.googleauthorKavitha Chinnaiyan-
dc.contributor.googleauthorBenjamin J W Chow-
dc.contributor.googleauthorEdoardo Conte-
dc.contributor.googleauthorRicardo C Cury-
dc.contributor.googleauthorGudrun Feuchtner-
dc.contributor.googleauthorMartin Hadamitzky-
dc.contributor.googleauthorYong-Jin Kim-
dc.contributor.googleauthorJonathon A Leipsic-
dc.contributor.googleauthorErica Maffei-
dc.contributor.googleauthorHugo Marques-
dc.contributor.googleauthorFabian Plank-
dc.contributor.googleauthorGianluca Pontone-
dc.contributor.googleauthorTodd C Villines-
dc.contributor.googleauthorMouaz H Al-Mallah-
dc.contributor.googleauthorPedro de Araújo Gonçalves-
dc.contributor.googleauthorIbrahim Danad-
dc.contributor.googleauthorYao Lu-
dc.contributor.googleauthorJi-Hyun Lee-
dc.contributor.googleauthorSang-Eun Lee-
dc.contributor.googleauthorLohendran Baskaran-
dc.contributor.googleauthorSubhi J Al'Aref-
dc.contributor.googleauthorMatthew J Budoff-
dc.contributor.googleauthorHabib Samady-
dc.contributor.googleauthorPeter H Stone-
dc.contributor.googleauthorRenu Virmani-
dc.contributor.googleauthorStephan Achenbach-
dc.contributor.googleauthorJagat Narula-
dc.contributor.googleauthorHyuk-Jae Chang-
dc.contributor.googleauthorLeslee J Shaw-
dc.contributor.googleauthorDaniel S Berman-
dc.contributor.googleauthorFay Lin-
dc.contributor.googleauthorDamini Dey-
dc.identifier.doiPurpose Pericoronary adipose tissue attenuation (PCATa) measured at coronary CT angiography (CCTA) is an imaging biomarker of coronary inflammation associated with long-term adverse cardiac events. The authors hypothesized that PCATa may independently identify patients at risk for acute coronary syndromes (ACS). Materials and Methods The authors performed a retrospective substudy of the Incident Coronary Syndromes Identified by Computed Tomography (ICONIC) study, a propensity-matched case-control study of patients with CCTA followed by ACS. Two hundred analyzable case and control pairs were identified from the original 234 pairs. PCATa was measured using the adjusted attenuation of fat around proximal coronary vessels. The primary analysis applied conditional Cox models with cluster-robust standard errors to predict patient-level incident ACS, with adjustment for quantitative plaque volumes and clinical reporting-oriented findings of maximal stenosis and high-risk plaque features (HRPF). Results A total of 400 patients with 1174 matched measurable vessels were included. PCATa was not significantly different between patients with future ACS versus controls (-72.99 HU ± 9.42 vs -73.96 HU ± 9.47; P = .08). Conversely, PCATa was significantly associated with incident ACS events in Cox models (adjusted for noncalcified plaque hazard ratio [HR]: 1.015; 95% CI: 1.001, 1.028; P = .03; adjusted for total plaque HR: 1.015; 95% CI: 1.002, 1.029; P = .03; adjusted for stenosis and HRPF HR: 1.014; 95% CI: 1.000, 1.028; P = .049). Conclusion Limited quantitative difference in PCATa between patients and controls matched for risk factors and coronary artery disease suggests that PCATa may not be a useful single marker to identify future ACS. Nonetheless, significant differences seen in adjusted survival models identify a small biologic effect for increased risk of future ACS independent of traditional risk factors.-
dc.contributor.localIdA03490-
dc.relation.journalcodeJ04445-
dc.identifier.eissn2638-6135-
dc.identifier.pmid40539913-
dc.subject.keywordAcute Coronary Syndrome* / diagnostic imaging-
dc.subject.keywordAdipose Tissue* / diagnostic imaging-
dc.subject.keywordAged-
dc.subject.keywordCase-Control Studies-
dc.subject.keywordComputed Tomography Angiography* / methods-
dc.subject.keywordCoronary Angiography* / methods-
dc.subject.keywordCoronary Vessels / diagnostic imaging-
dc.subject.keywordEpicardial Adipose Tissue-
dc.subject.keywordFemale-
dc.subject.keywordHumans-
dc.subject.keywordMale-
dc.subject.keywordMiddle Aged-
dc.subject.keywordRetrospective Studies-
dc.contributor.alternativeNameChang, Hyuck Jae-
dc.contributor.affiliatedAuthor장혁재-
dc.citation.volume7-
dc.citation.number3-
dc.citation.startPagee240200-
dc.identifier.bibliographicCitationRADIOLOGY-CARDIOTHORACIC IMAGING, Vol.7(3) : e240200, 2025-06-
dc.identifier.articleno10.1148/ryct.240200-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Show simple item record Find it @ YMLIB

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

  • License
    sherpa_romeo
    sherpa_juliet

OAK

DSpace Software Copyright © 2002-2017 Duraspace Yonsei University Medical Library All right Reserves. / TEL:02-2228-2915 /
YUHSpace는 국립중앙도서관 OAK 보급사업으로 구축되었습니다.

Browse

Links