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Spatially Resolved Tumor Ecosystems and Cell States in Gastric Adenocarcinoma Progression and Evolution

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dc.contributor.author라선영-
dc.date.accessioned2025-07-17T03:19:22Z-
dc.date.available2025-07-17T03:19:22Z-
dc.date.issued2025-04-
dc.identifier.issn2159-8274-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/206660-
dc.description.abstractIntegration of spatial transcriptomic (GeoMx Digital Spatial Profiler) and single-cell RNA sequencing data from multiple gastric cancers identifies spatially resolved expression-based intratumoral heterogeneity, associated with distinct immune microenvironments. We uncovered two separate evolutionary trajectories associated with specific molecular subtypes, clinical prognoses, stromal neighborhoods, and genetic drivers. Tumor-stroma interfaces emerged as a unique state of tumor ecology.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherAmerican Association for Cancer Research-
dc.relation.isPartOfCANCER DISCOVERY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdenocarcinoma* / genetics-
dc.subject.MESHAdenocarcinoma* / pathology-
dc.subject.MESHDisease Progression-
dc.subject.MESHHumans-
dc.subject.MESHSingle-Cell Analysis-
dc.subject.MESHStomach Neoplasms* / genetics-
dc.subject.MESHStomach Neoplasms* / pathology-
dc.subject.MESHTumor Microenvironment* / genetics-
dc.titleSpatially Resolved Tumor Ecosystems and Cell States in Gastric Adenocarcinoma Progression and Evolution-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorHaoran Ma-
dc.contributor.googleauthorSupriya Srivastava-
dc.contributor.googleauthorShamaine Wei Ting Ho-
dc.contributor.googleauthorChang Xu-
dc.contributor.googleauthorBenedict Shi Xiang Lian-
dc.contributor.googleauthorXuewen Ong-
dc.contributor.googleauthorSu Ting Tay-
dc.contributor.googleauthorTaotao Sheng-
dc.contributor.googleauthorHuey Yew Jeffrey Lum-
dc.contributor.googleauthorSiti Aishah Binte Abdul Ghani-
dc.contributor.googleauthorYunqiang Chu-
dc.contributor.googleauthorKie Kyon Huang-
dc.contributor.googleauthorYeek Teck Goh-
dc.contributor.googleauthorMinghui Lee-
dc.contributor.googleauthorTakeshi Hagihara-
dc.contributor.googleauthorClara Shi Ya Ng-
dc.contributor.googleauthorAngie Lay Keng Tan-
dc.contributor.googleauthorYanrong Zhang-
dc.contributor.googleauthorZichen Ding-
dc.contributor.googleauthorFeng Zhu-
dc.contributor.googleauthorMichelle Shu Wen Ng-
dc.contributor.googleauthorCraig Ryan Cecil Joseph-
dc.contributor.googleauthorHui Chen-
dc.contributor.googleauthorZhen Li-
dc.contributor.googleauthorJoseph J Zhao-
dc.contributor.googleauthorSun Young Rha-
dc.contributor.googleauthorMing Teh-
dc.contributor.googleauthorJoe Yeong-
dc.contributor.googleauthorWei Peng Yong-
dc.contributor.googleauthorJimmy Bok-Yan So-
dc.contributor.googleauthorRaghav Sundar-
dc.contributor.googleauthorPatrick Tan-
dc.identifier.doi10.1158/2159-8290.CD-24-0605-
dc.contributor.localIdA01316-
dc.relation.journalcodeJ03328-
dc.identifier.eissn2159-8290-
dc.identifier.pmid39774838-
dc.contributor.alternativeNameRha, Sun Young-
dc.contributor.affiliatedAuthor라선영-
dc.citation.volume15-
dc.citation.number4-
dc.citation.startPage767-
dc.citation.endPage792-
dc.identifier.bibliographicCitationCANCER DISCOVERY, Vol.15(4) : 767-792, 2025-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
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