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Histopathological characteristics of Epstein-Barr virus (EBV)-associated encephalitis and colitis in chronic active EBV infection

Authors
 Betty A Kasimo  ;  James J Yahaya  ;  Sun Och Yoon  ;  Se Hoon Kim  ;  Minsun Jung 
Citation
 JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE, Vol.59(3) : 188-194, 2025-04 
Journal Title
JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE
ISSN
 2383-7837 
Issue Date
2025-04
Keywords
Colitis ; Encephalitis, viral ; Epstein-Barr virus infections ; Lymphoproliferative disorders
Abstract
Chronic active Epstein-Barr virus (CAEBV) can induce complications in various organs, including the brain and gastrointestinal tract. A 3-year-old boy was referred to the hospital with a history of fever and seizures for 15 days. A diagnosis of encephalitis based on computed tomography (CT) and magnetic resonance imaging findings and clinical correlation was made. Laboratory tests showed positive serology for Epstein-Barr virus (EBV) and negative for Rotavirus antigen and IgG and IgM antibodies for cytomegalovirus, herpes simplex virus, and varicella zoster virus, respectively. Abdominal CT showed diffuse wall thickening with fluid distension of small bowel loops, lower abdomen wall thickening, and a small amount of ascites. The biopsy demonstrated positive Epstein-Barr encoding region in situ hybridization in cells within the crypts and lamina propria. The patient was managed with steroids and hematopoietic stem cell transplantation (HSCT). This case showed histopathological characteristics of concurrent EBV-associated encephalitis and colitis in CAEBV infection. The three-step strategy of immunosuppressive therapy, chemotherapy, and allogeneic HSCT should be always be considered for prevention of disease progression.
Files in This Item:
T202503067.pdf Download
DOI
10.4132/jptm.2025.02.21
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Hoon(김세훈) ORCID logo https://orcid.org/0000-0001-7516-7372
Yoon, Sun Ock(윤선옥) ORCID logo https://orcid.org/0000-0002-5115-1402
Jung, Minsun(정민선) ORCID logo https://orcid.org/0000-0002-8701-4282
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/206076
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