Revisiting T Cells in Chronic Rhinosinusitis

Abstract

A variety of immune cells in the nasal tissue are involved in the immunopathogenesis of chronic rhinosinusitis (CRS), a chronic inflammatory disease affecting the nasal cavity and paranasal sinuses. T cells play a pivotal role in orchestrating immune dysregulation in CRS by producing key cytokines. Recent studies have expanded the understanding of T cell biology across the inflammatory endotypes of CRS. This review summarizes current knowledge on the multifaceted roles of T cells in the pathophysiology of CRS. Particularly, we highlight the alterations in phenotypes and functions of various T cell subsets in CRS. Additionally, as functional studies of effector and regulatory T cell populations have revealed potential translational targets, we suggest perspectives for future research into T cell-oriented therapeutic strategies for CRS.