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The development status of PET radiotracers for evaluating neuroinflammation

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dc.contributor.authorLee, Namhun-
dc.contributor.authorChoi, Jae Yong-
dc.contributor.authorRyu, Young Hoon-
dc.date.accessioned2024-12-06T03:14:39Z-
dc.date.available2024-12-06T03:14:39Z-
dc.date.created2025-07-02-
dc.date.issued2024-06-
dc.identifier.issn1869-3474-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/201018-
dc.description.abstractNeuroinflammation is associated with the pathophysiologies of neurodegenerative and psychiatric disorders. Evaluating neuroinflammation using positron emission tomography (PET) plays an important role in the early diagnosis and determination of proper treatment of brain diseases. To quantify neuroinflammatory responses in vivo, many PET tracers have been developed using translocator proteins, imidazole-2 binding site, cyclooxygenase, monoamine oxidase-B, adenosine, cannabinoid, purinergic P2X7, and CSF-1 receptors as biomarkers. In this review, we introduce the latest developments in PET tracers that can image neuroinflammation, focusing on clinical trials, and further consider their current implications.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.publisherKorean Society of Nuclear Medicine-
dc.relation.isPartOfNUCLEAR MEDICINE AND MOLECULAR IMAGING-
dc.relation.isPartOfNUCLEAR MEDICINE AND MOLECULAR IMAGING-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleThe development status of PET radiotracers for evaluating neuroinflammation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Nuclear Medicine (핵의학교실)-
dc.contributor.googleauthorLee, Namhun-
dc.contributor.googleauthorChoi, Jae Yong-
dc.contributor.googleauthorRyu, Young Hoon-
dc.identifier.doi10.1007/s13139-023-00831-4-
dc.relation.journalcodeJ02382-
dc.identifier.eissn1869-3482-
dc.identifier.pmid38932754-
dc.subject.keywordNeuroinflammation-
dc.subject.keywordMicroglia-
dc.subject.keywordAstrocyte-
dc.subject.keywordPositron emission tomography-
dc.subject.keywordRadiotracer-
dc.contributor.alternativeNameRyu, Young Hoon-
dc.contributor.affiliatedAuthorRyu, Young Hoon-
dc.identifier.scopusid2-s2.0-85181731467-
dc.identifier.wosid001137681800001-
dc.citation.volume58-
dc.citation.number4-
dc.citation.startPage160-
dc.citation.endPage176-
dc.identifier.bibliographicCitationNUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol.58(4) : 160-176, 2024-06-
dc.identifier.rimsid87401-
dc.type.rimsART-
dc.description.journalClass1-
dc.description.journalClass1-
dc.subject.keywordAuthorNeuroinflammation-
dc.subject.keywordAuthorMicroglia-
dc.subject.keywordAuthorAstrocyte-
dc.subject.keywordAuthorPositron emission tomography-
dc.subject.keywordAuthorRadiotracer-
dc.subject.keywordPlusPOSITRON-EMISSION-TOMOGRAPHY-
dc.subject.keywordPlusPERIPHERAL BENZODIAZEPINE-RECEPTORS-
dc.subject.keywordPlusMONOAMINE-OXIDASE-B-
dc.subject.keywordPlusIN-VIVO EVALUATION-
dc.subject.keywordPlusADENOSINE A(2A) RECEPTORS-
dc.subject.keywordPlusPROTEIN 18 KDA-
dc.subject.keywordPlus18-KDA TRANSLOCATOR PROTEIN-
dc.subject.keywordPlusHUMAN-BRAIN-
dc.subject.keywordPlusPRECLINICAL EVALUATION-
dc.subject.keywordPlusACTIVATED MICROGLIA-
dc.type.docTypeReview-
dc.identifier.kciidART003107665-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.relation.journalWebOfScienceCategoryRadiology, Nuclear Medicine & Medical Imaging-
dc.relation.journalResearchAreaRadiology, Nuclear Medicine & Medical Imaging-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
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