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Investigation of cell-to-cell transfer of polystyrene microplastics through extracellular vesicle-mediated communication

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dc.contributor.author박주현-
dc.contributor.author이인하-
dc.contributor.author이재훈-
dc.contributor.author임우석-
dc.contributor.author조시현-
dc.contributor.author최영식-
dc.date.accessioned2024-12-06T02:47:24Z-
dc.date.available2024-12-06T02:47:24Z-
dc.date.issued2024-11-
dc.identifier.issn0006-291X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/200900-
dc.description.abstractPlastics are an essential part of human life and their production is increasing every year. Plastics degrade into small particles (<5 mm, microplastics, MPs) in the environment due to various factors. MPs are widely distributed in the environment, and all living organisms are exposed to the effects of MPs. Extracellular vesicles (EVs) are small membrane particles surrounded by a lipid bilayer that are released into the environment by various cell types and are highly involved in inter- and intra-cellular communication through the exchange of proteins, nucleic acids, and lipids between cells. There have been numerous reports of adverse effects associated with the accumulation of MPs in human and animal cells, with recent studies showing that plastic treatment increases the number of EVs released from cells, but the mechanisms by which MPs accumulate and move between cells remain unclear. In this study, we investigated whether polystyrene (PS)-MPs are transferred cell-to-cell via EVs. This study showed that cell-derived EVs can transport plastic particles. Furthermore, we confirmed the accumulation of PS-MPs transported by EVs within cells using a real-time imaging device. This study provides an understanding of potential EVs-mediated effects of PS-MPs on organisms and suggests directions for further research.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnimals-
dc.subject.MESHBiological Transport-
dc.subject.MESHCell Communication*-
dc.subject.MESHCell Line-
dc.subject.MESHExtracellular Vesicles* / metabolism-
dc.subject.MESHHumans-
dc.subject.MESHMicroplastics* / metabolism-
dc.subject.MESHMicroplastics* / toxicity-
dc.subject.MESHPolystyrenes* / chemistry-
dc.subject.MESHPolystyrenes* / metabolism-
dc.titleInvestigation of cell-to-cell transfer of polystyrene microplastics through extracellular vesicle-mediated communication-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Obstetrics and Gynecology (산부인과학교실)-
dc.contributor.googleauthorNara Kim-
dc.contributor.googleauthorJoo Hyun Park-
dc.contributor.googleauthorInha Lee-
dc.contributor.googleauthorGee Soo Jung-
dc.contributor.googleauthorJae Hoon Lee-
dc.contributor.googleauthorMin Jung Lee-
dc.contributor.googleauthorWooseok Im-
dc.contributor.googleauthorSiHyun Cho-
dc.contributor.googleauthorYoung Sik Choi-
dc.identifier.doi10.1016/j.bbrc.2024.150719-
dc.contributor.localIdA01668-
dc.contributor.localIdA05497-
dc.contributor.localIdA04636-
dc.contributor.localIdA06320-
dc.contributor.localIdA03846-
dc.contributor.localIdA04114-
dc.relation.journalcodeJ00281-
dc.identifier.eissn1090-2104-
dc.identifier.pmid39362032-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0006291X24012555-
dc.subject.keywordEnvironmental pollution-
dc.subject.keywordExtracellular vesicles-
dc.subject.keywordIshikawa cells-
dc.subject.keywordMicroplastics-
dc.subject.keywordTransfer-
dc.contributor.alternativeNamePark, Joo Hyun-
dc.contributor.affiliatedAuthor박주현-
dc.contributor.affiliatedAuthor이인하-
dc.contributor.affiliatedAuthor이재훈-
dc.contributor.affiliatedAuthor임우석-
dc.contributor.affiliatedAuthor조시현-
dc.contributor.affiliatedAuthor최영식-
dc.citation.volume734-
dc.citation.startPage150719-
dc.identifier.bibliographicCitationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.734 : 150719, 2024-11-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers

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