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Revisiting oligodendroglioma grading in the 2021 WHO classification: calcification and larger contrast-enhancing tumor volume may predict higher oligodendroglioma grade

Authors
 Doo Young Lee  ;  Ka Eum Choi  ;  Kyunghwa Han  ;  Seo Hee Choi  ;  Narae Lee  ;  Sung Soo Ahn  ;  Jong Hee Chang  ;  Se Hoon Kim  ;  Seung-Koo Lee  ;  Yae Won Park 
Citation
 NEURORADIOLOGY, Vol.66(9) : 1527-1535, 2024-09 
Journal Title
NEURORADIOLOGY
ISSN
 0028-3940 
Issue Date
2024-09
MeSH
Adult ; Aged ; Brain Neoplasms* / diagnostic imaging ; Brain Neoplasms* / genetics ; Brain Neoplasms* / pathology ; Calcinosis* / diagnostic imaging ; Calcinosis* / pathology ; Contrast Media* ; Female ; Humans ; Magnetic Resonance Imaging* / methods ; Male ; Middle Aged ; Neoplasm Grading* ; Oligodendroglioma* / diagnostic imaging ; Oligodendroglioma* / genetics ; Oligodendroglioma* / pathology ; Predictive Value of Tests ; Retrospective Studies ; Tumor Burden* ; World Health Organization
Keywords
Grade ; Magnetic resonance imaging ; Oligodendroglioma ; World Health Organization
Abstract
Purpose To investigate whether qualitative and quantitative imaging phenotypes can predict the grade of oligodendroglioma. Methods Retrospective chart and imaging reviews were conducted on 180 adults with oligodendroglioma (IDH-mutant and 1p/19q codeleted) between 2005 and 2021. Qualitative imaging characteristics including tumor location, calcification, gliomatosis cerebri, cystic change, necrosis, and infiltrative pattern were analyzed. Quantitative imaging assessment was performed from the tumor mask via automatic segmentation to calculate total, contrast-enhancing (CE), non-enhancing (NE), and necrotic tumor volumes. Logistic analyses were conducted to determine predictors of oligodendroglioma grade. Results This study included 180 patients (84 [46.7%] with grade 2 and 96 [53.3%] with grade 3 oligodendrogliomas), with a median age of 42 years (range 23-76 years), comprising 91 females and 89 males. On univariable analysis, calcification (odds ratio [OR] = 6.00, P < 0.001), necrosis (OR = 21.84, P = 0.003), presence of CE tumor (OR = 7.86, P < 0.001), larger total (OR = 1.01, P < 0.001), larger CE (OR = 2.22, P = 0.010), and larger NE (OR = 1.01, P < 0.001) tumor volumes were predictors of grade 3 oligodendroglioma. On multivariable analysis, calcification (OR = 3.79, P < 0.001) and larger CE tumor volume (OR = 2.70, P = 0.043) remained as independent predictors of grade 3 oligodendroglioma. The multivariable model exhibited an AUC, accuracy, sensitivity, specificity of 0.78 (95% confidence interval 0.72-0.84), 72.8%, 79.2%, 69.1%, respectively. Conclusion Presence of calcification and larger CE tumor volume may serve as useful imaging biomarkers for prediction of oligodendroglioma grade. Clinical Relevance Statement Assessment of intratumoral calcification and CE tumor volume may facilitate accurate preoperative estimation of oligodendroglioma grade. Summary statement Presence of intratumoral calcification and larger contrast-enhancing tumor volume were the significant predictors of higher grade oligodendroglioma based on the 2021 WHO classification.
Full Text
https://link.springer.com/article/10.1007/s00234-024-03430-y
DOI
10.1007/s00234-024-03430-y
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Hoon(김세훈) ORCID logo https://orcid.org/0000-0001-7516-7372
Park, Yae Won(박예원) ORCID logo https://orcid.org/0000-0001-8907-5401
Ahn, Sung Soo(안성수) ORCID logo https://orcid.org/0000-0002-0503-5558
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
Chang, Jong Hee(장종희) ORCID logo https://orcid.org/0000-0003-1509-9800
Choi, Seo Hee(최서희) ORCID logo https://orcid.org/0000-0002-4083-6414
Han, Kyung Hwa(한경화)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/200729
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