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Exploring aryl hydrocarbon receptor expression and distribution in the tumor microenvironment, with a focus on immune cells, in various solid cancer types

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dc.contributor.author이기쁨-
dc.contributor.author임선민-
dc.contributor.author조병철-
dc.contributor.author표경호-
dc.contributor.author홍민희-
dc.date.accessioned2024-10-04T02:43:58Z-
dc.date.available2024-10-04T02:43:58Z-
dc.date.issued2024-04-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/200577-
dc.description.abstractIntroduction Aryl hydrocarbon receptor (AhR) is a transcription factor that performs various functions upon ligand activation. Several studies have explored the role of AhR expression in tumor progression and immune surveillance. Nevertheless, investigations on the distribution of AhR expression, specifically in cancer or immune cells in the tumor microenvironment (TME), remain limited. Examining the AhR expression and distribution in the TME is crucial for gaining insights into the mechanism of action of AhR-targeting anticancer agents and their potential as biomarkers.Methods Here, we used multiplexed immunohistochemistry (mIHC) and image cytometry to investigate the AhR expression and distribution in 513 patient samples, of which 292 are patients with one of five solid cancer types. Additionally, we analyzed the nuclear and cytosolic distribution of AhR expression.Results Our findings reveal that AhR expression was primarily localized in cancer cells, followed by stromal T cells and macrophages. Furthermore, we observed a positive correlation between the nuclear and cytosolic expression of AhR, indicating that the expression of AhR as a biomarker is independent of its localization. Interestingly, the expression patterns of AhR were categorized into three clusters based on the cancer type, with high AhR expression levels being found in regulatory T cells (Tregs) in non-small cell lung cancer (NSCLC).Discussion These findings are anticipated to serve as pivotal evidence for the design of clinical trials and the analysis of the anticancer mechanisms of AhR-targeting therapies.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherFrontiers Research Foundation-
dc.relation.isPartOfFRONTIERS IN IMMUNOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHBasic Helix-Loop-Helix Transcription Factors / metabolism-
dc.subject.MESHBiomarkers, Tumor / metabolism-
dc.subject.MESHHumans-
dc.subject.MESHNeoplasms* / immunology-
dc.subject.MESHNeoplasms* / metabolism-
dc.subject.MESHNeoplasms* / pathology-
dc.subject.MESHReceptors, Aryl Hydrocarbon* / metabolism-
dc.subject.MESHTumor Microenvironment* / immunology-
dc.titleExploring aryl hydrocarbon receptor expression and distribution in the tumor microenvironment, with a focus on immune cells, in various solid cancer types-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorDong Kwon Kim-
dc.contributor.googleauthorChai Young Lee-
dc.contributor.googleauthorYu Jin Han-
dc.contributor.googleauthorSo Young Park-
dc.contributor.googleauthorHeekyung Han-
dc.contributor.googleauthorKwangmin Na-
dc.contributor.googleauthorMi Hyun Kim-
dc.contributor.googleauthorSeung Min Yang-
dc.contributor.googleauthorSujeong Baek-
dc.contributor.googleauthorYoungtaek Kim-
dc.contributor.googleauthorJoon Yeon Hwang-
dc.contributor.googleauthorSeul Lee-
dc.contributor.googleauthorSeong-San Kang-
dc.contributor.googleauthorMin Hee Hong-
dc.contributor.googleauthorSun Min Lim-
dc.contributor.googleauthorJii Bum Lee-
dc.contributor.googleauthorJae Hwan Kim-
dc.contributor.googleauthorByoung Chul Cho-
dc.contributor.googleauthorKyoung-Ho Pyo-
dc.identifier.doi38680496-
dc.contributor.localIdA05930-
dc.contributor.localIdA03369-
dc.contributor.localIdA03822-
dc.contributor.localIdA04809-
dc.contributor.localIdA04393-
dc.relation.journalcodeJ03075-
dc.identifier.eissn1664-3224-
dc.identifier.pmid10.3389/fimmu.2024.1330228-
dc.subject.keywordT-lymphocyte-
dc.subject.keywordaryl hydrocarbon receptor-
dc.subject.keywordmacrophage-
dc.subject.keywordregulatory T cell-
dc.subject.keywordtumor microenvironment-
dc.contributor.alternativeNameLee, Jii Bum-
dc.contributor.affiliatedAuthor이기쁨-
dc.contributor.affiliatedAuthor임선민-
dc.contributor.affiliatedAuthor조병철-
dc.contributor.affiliatedAuthor표경호-
dc.contributor.affiliatedAuthor홍민희-
dc.citation.volume15-
dc.citation.startPage1330228-
dc.identifier.bibliographicCitationFRONTIERS IN IMMUNOLOGY, Vol.15 : 1330228, 2024-04-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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