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Four genotypes of carbapenem-resistant Acinetobacter baumannii strains lacking OXA-23 production in Korea
DC Field | Value | Language |
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dc.contributor.author | 정석훈 | - |
dc.date.accessioned | 2024-07-18T05:26:46Z | - |
dc.date.available | 2024-07-18T05:26:46Z | - |
dc.date.issued | 2024-06 | - |
dc.identifier.issn | 2288-0585 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/200096 | - |
dc.description.abstract | During nationwide Fantimicrobial surveillance (Korea Global Antimicrobial ResistanceSurveillance System [Kor-GLASS]), the recent emergence of non-oxacillinase (OXA)-23 production by carbapenem-resistant Acinetobacter baumannii (CRAB) isolates wasnoted. In this study, we evaluated resistance mechanisms other than OXA-23 productionto elucidate the shift in considerable CRAB clones. The presence of OXA carbapenemasegenes, such as blaOXA-23, blaOXA-24, blaOXA-58, and blaOXA-51-ISAba1, was determined by PCR. Other carbapenemase genes, such as blaIMP, blaVIM, blaNDM, blaKPC, blaGES, and blaOXA-48, weredetermined using sequencing. Strains lacking carbapenemase genes were subjected towhole genome sequencing, and resistance genes were analyzed using ResFinder. Four CRABstrains were collected through a Kor-GLASS study in 2022, in which OXA-23 production wasnot identified. The carbapenemase genotypes of the four CRAB strains lacking blaOXA-23 werebla OXA-51-ISAba1, blaOXA-66/ACD25, blaOXA-182, and blaNDM-1. To the best of our knowledge, this is thefirst study to identify CRAB producing New Delhi metallo-β-lactamase (NDM)-1 in Korea. Inconclusion, domestic CRAB resistance mechanisms may undergo subtle changes. Continuousobservations are required to monitor the emergence of new clones. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Society of Clinical Microbiology | - |
dc.relation.isPartOf | Annals of Clinical Microbiology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Four genotypes of carbapenem-resistant Acinetobacter baumannii strains lacking OXA-23 production in Korea | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.googleauthor | Young Ah Kim | - |
dc.contributor.googleauthor | Seok Hoon Jeong | - |
dc.contributor.googleauthor | Jong Hee Shin4 | - |
dc.contributor.googleauthor | Kyeong Seob Shin | - |
dc.contributor.googleauthor | Jeong Hwan Shin | - |
dc.contributor.googleauthor | Young Ree Kim | - |
dc.contributor.googleauthor | Hyun Soo Kim | - |
dc.contributor.googleauthor | Young Uh | - |
dc.contributor.googleauthor | Nam Hee Ryoo | - |
dc.identifier.doi | 10.5145/ACM.2024.27.2.8 | - |
dc.contributor.localId | A03619 | - |
dc.relation.journalcode | J00156 | - |
dc.identifier.eissn | 2288-6850 | - |
dc.subject.keyword | Carbapenem | - |
dc.subject.keyword | Resistance | - |
dc.subject.keyword | Acinetobacter baumannii | - |
dc.subject.keyword | NDM-1 | - |
dc.subject.keyword | OXA-23 | - |
dc.contributor.alternativeName | Jeong, Seok Hoon | - |
dc.contributor.affiliatedAuthor | 정석훈 | - |
dc.citation.volume | 27 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 143 | - |
dc.citation.endPage | 147 | - |
dc.identifier.bibliographicCitation | Annals of Clinical Microbiology, Vol.27(2) : 143-147, 2024-06 | - |
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