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Dose-toxicity surface histogram-based prediction of radiation dermatitis severity and shape

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dc.contributor.author김동욱-
dc.contributor.author김진성-
dc.contributor.author김창환-
dc.contributor.author김호진-
dc.contributor.author이호-
dc.contributor.author최서희-
dc.contributor.author한민철-
dc.contributor.author홍채선-
dc.date.accessioned2024-07-18T05:24:51Z-
dc.date.available2024-07-18T05:24:51Z-
dc.date.issued2024-06-
dc.identifier.issn0031-9155-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/200087-
dc.description.abstractObjective. This study aimed to develop a new approach to predict radiation dermatitis (RD) by using the skin dose distribution in the actual area of RD occurrence to determine the predictive dose by grade. Approach. Twenty-three patients with head and neck cancer treated with volumetric modulated arc therapy were prospectively and retrospectively enrolled. A framework was developed to segment the RD occurrence area in skin photography by matching the skin surface image obtained using a 3D camera with the skin dose distribution. RD predictive doses were generated using the dose-toxicity surface histogram (DTH) calculated from the skin dose distribution within the segmented RD regions classified by severity. We then evaluated whether the developed DTH-based framework could visually predict RD grades and their occurrence areas and shapes according to severity. Main results. The developed framework successfully generated the DTH for three different RD severities: faint erythema (grade 1), dry desquamation (grade 2), and moist desquamation (grade 3); 48 DTHs were obtained from 23 patients: 23, 22, and 3 DTHs for grades 1, 2, and 3, respectively. The RD predictive doses determined using DTHs were 28.9 Gy, 38.1 Gy, and 54.3 Gy for grades 1, 2, and 3, respectively. The estimated RD occurrence area visualized by the DTH-based RD predictive dose showed acceptable agreement for all grades compared with the actual RD region in the patient. The predicted RD grade was accurate, except in two patients. Significance. The developed DTH-based framework can classify and determine RD predictive doses according to severity and visually predict the occurrence area and shape of different RD severities. The proposed approach can be used to predict the severity and shape of potential RD in patients and thus aid physicians in decision making.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherIOP Publishing-
dc.relation.isPartOfPHYSICS IN MEDICINE AND BIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAged-
dc.subject.MESHFemale-
dc.subject.MESHHead and Neck Neoplasms / radiotherapy-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRadiation Dosage-
dc.subject.MESHRadiodermatitis* / etiology-
dc.subject.MESHRadiotherapy Dosage-
dc.subject.MESHRadiotherapy, Intensity-Modulated / adverse effects-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHSkin / diagnostic imaging-
dc.subject.MESHSkin / pathology-
dc.subject.MESHSkin / radiation effects-
dc.titleDose-toxicity surface histogram-based prediction of radiation dermatitis severity and shape-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학교실)-
dc.contributor.googleauthorChae-Seon Hong-
dc.contributor.googleauthorYe-In Park-
dc.contributor.googleauthorMin-Seok Cho-
dc.contributor.googleauthorJunyoung Son-
dc.contributor.googleauthorChanghwan Kim-
dc.contributor.googleauthorMin Cheol Han-
dc.contributor.googleauthorHojin Kim-
dc.contributor.googleauthorHo Lee-
dc.contributor.googleauthorDong Wook Kim-
dc.contributor.googleauthorSeo Hee Choi-
dc.contributor.googleauthorJin Sung Kim-
dc.identifier.doi10.1088/1361-6560/ad4d4e-
dc.contributor.localIdA05710-
dc.contributor.localIdA04548-
dc.contributor.localIdA06353-
dc.contributor.localIdA05970-
dc.contributor.localIdA03323-
dc.contributor.localIdA04867-
dc.contributor.localIdA05870-
dc.contributor.localIdA05846-
dc.relation.journalcodeJ02523-
dc.identifier.eissn1361-6560-
dc.identifier.pmid38759672-
dc.identifier.urlhttps://iopscience.iop.org/article/10.1088/1361-6560/ad4d4e-
dc.subject.keyworddose-toxicity surface histogram-
dc.subject.keywordpredictive factor-
dc.subject.keywordradiation dermatitis-
dc.subject.keywordradiation therapy-
dc.subject.keywordsegmentation-
dc.subject.keywordskin dose-
dc.subject.keywordskin toxicity-
dc.contributor.alternativeNameKim, Dong Wook-
dc.contributor.affiliatedAuthor김동욱-
dc.contributor.affiliatedAuthor김진성-
dc.contributor.affiliatedAuthor김창환-
dc.contributor.affiliatedAuthor김호진-
dc.contributor.affiliatedAuthor이호-
dc.contributor.affiliatedAuthor최서희-
dc.contributor.affiliatedAuthor한민철-
dc.contributor.affiliatedAuthor홍채선-
dc.citation.volume69-
dc.citation.number11-
dc.citation.startPage115041-
dc.identifier.bibliographicCitationPHYSICS IN MEDICINE AND BIOLOGY, Vol.69(11) : 115041, 2024-06-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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