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The Relation Between Cigarette Smoking and Development of Sepsis: A 10-Year Follow-Up Study of Four Million Adults from the National Health Screening Program
DC Field | Value | Language |
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dc.contributor.author | 이경화 | - |
dc.contributor.author | 이은화 | - |
dc.contributor.author | 한상훈 | - |
dc.date.accessioned | 2024-07-18T05:17:37Z | - |
dc.date.available | 2024-07-18T05:17:37Z | - |
dc.date.issued | 2024-06 | - |
dc.identifier.issn | 2210-6006 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/200051 | - |
dc.description.abstract | Background: Sepsis remains a growing global health concern with soaring mortality and no direct anti-sepsis drug. Although smoking has distinct deleterious effects on chronic inflammatory illnesses and can impair immune function, a comprehensive analysis of the connection between sepsis and smoking is lacking. Methods: This large-scale longitudinal cohort study retrospectively assessed adults aged ≥ 20 years who underwent national health checkups under the Korean National Health Insurance Service between January and December 2009 (N = 4,234,415) and were followed up for 10 years. Sepsis was identified based on the International Classification of Diseases, 10th Revision codes, and smoking status, including accumulated amount, was collected through a self-administered questionnaire. The Cox proportional hazard regression model was used, adjusting for age, sex, household income, body mass index, drinking, exercise, diabetes, hypertension, dyslipidemia, and chronic renal disease. Results: After excluding cases with sepsis occurring before follow-up or after ≤ 1 year of follow-up, 3,881,958 participants, including non-smokers (N = 2,342,841), former smokers (N = 539,850), and active smokers (N = 999,267), were included. Compared to non-smokers, all active smokers (adjust hazard ratio: 1.41, 95% confidence interval 1.38-1.44) and former smokers (1.10, 1.07-1.14) with ≥ 20 pack-years exhibited a significantly higher risk of sepsis (p < 0.001). Smoking of ≥ 30 pack-years in former and active smokers groups significantly increased sepsis incidence (adjust hazard ratio [95% confidence interval] 1.34 [1.31-1.38], p < 0.001). Conclusions: Smoking is closely associated with the incidence of sepsis. Smoking cessation may help in the primary prevention of sepsis. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | J Epidemiol Glob Health | - |
dc.relation.isPartOf | JOURNAL OF EPIDEMIOLOGY AND GLOBAL HEALTH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Cigarette Smoking* / adverse effects | - |
dc.subject.MESH | Cigarette Smoking* / epidemiology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Longitudinal Studies | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | National Health Programs / statistics & numerical data | - |
dc.subject.MESH | Republic of Korea / epidemiology | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Sepsis* / epidemiology | - |
dc.subject.MESH | Sepsis* / etiology | - |
dc.subject.MESH | Young Adult | - |
dc.title | The Relation Between Cigarette Smoking and Development of Sepsis: A 10-Year Follow-Up Study of Four Million Adults from the National Health Screening Program | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Eun Hwa Lee | - |
dc.contributor.googleauthor | Kyoung Hwa Lee | - |
dc.contributor.googleauthor | Kyu-Na Lee | - |
dc.contributor.googleauthor | Yebin Park | - |
dc.contributor.googleauthor | Kyung Do Han | - |
dc.contributor.googleauthor | Sang Hoon Han | - |
dc.identifier.doi | 10.1007/s44197-024-00197-6 | - |
dc.contributor.localId | A04620 | - |
dc.contributor.localId | A06176 | - |
dc.contributor.localId | A04286 | - |
dc.relation.journalcode | J04519 | - |
dc.identifier.eissn | 2210-6014 | - |
dc.identifier.pmid | 38372892 | - |
dc.subject.keyword | Cigarette smoking | - |
dc.subject.keyword | Cumulative amount | - |
dc.subject.keyword | Incidence | - |
dc.subject.keyword | Pack-year | - |
dc.subject.keyword | Sepsis | - |
dc.contributor.alternativeName | Lee, Kyoung Hwa | - |
dc.contributor.affiliatedAuthor | 이경화 | - |
dc.contributor.affiliatedAuthor | 이은화 | - |
dc.contributor.affiliatedAuthor | 한상훈 | - |
dc.citation.volume | 14 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 444 | - |
dc.citation.endPage | 452 | - |
dc.identifier.bibliographicCitation | JOURNAL OF EPIDEMIOLOGY AND GLOBAL HEALTH, Vol.14(2) : 444-452, 2024-06 | - |
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