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Carbapenem-resistant gram-negative rod bacteremia in the early postoperative period following liver transplantation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김덕기 | - |
dc.contributor.author | 김명수 | - |
dc.contributor.author | 이재근 | - |
dc.contributor.author | 주동진 | - |
dc.date.accessioned | 2024-07-18T05:16:06Z | - |
dc.date.available | 2024-07-18T05:16:06Z | - |
dc.date.issued | 2024-05 | - |
dc.identifier.issn | 2765-5121 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/200045 | - |
dc.description.abstract | Background: Carbapenem-resistant gram-negative rod bacteremia (CRGNR-B) is emerging as a formidable challenge, complicating patient management and outcomes in liver transplantation (LT). This study aimed to investigate the incidence, mortality, and risk factors associated with CRGNR-B within 90 days following LT. Methods: A retrospective nested case-control study was conducted using single centric LT data (n=1,379). CRGNR-B cases were matched 1:5 with control patients for analyzing survival and risk factors for CRGNR-B. Results: The incidence of CRGNR-B within 90 days post-LT was 6.5% (n=87). The CRGNR-B group showed significantly lower 1-year post-LT survival compared to the control group (37.9% vs. 90.0%, p<0.001). CRGNR-B was significantly correlated with increased mortality after adjustment of covariates (adjusted hazard ratio, 5.66; 95% confidence interval [CI], 3.89–8.24; p<0.001). Key risk factors identified include higher pretransplant model for end-stage liver disease scores (odds ratio [OR], 1.05; 95% CI, 1.01–1.09; p=0.006), encephalopathy prior to transplant (OR, 2.79; 95% CI, 1.48–5.30; p=0.002), retransplantation (OR, 10.4; 95% CI, 2.79–42.1; p<0.001), each 60-minute increase in cold ischemic time (OR, 1.20; 95% CI, 1.01–1.42; p=0.037), and bile duct complications (OR, 6.16; 95% CI, 2.66–14.2; p<0.001). Conclusion: The occurrence of CRGNR-B within 90 days post-LT poses a significant risk to patient survival, with identifiable pre- and peri-transplant risk factors. These findings underscore the importance of targeted preventive measures, early detection, and effective management strategies to enhance outcomes for LT recipients. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Liver Transplantation Society | - |
dc.relation.isPartOf | Annals of Liver Transplantation | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Carbapenem-resistant gram-negative rod bacteremia in the early postoperative period following liver transplantation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Eun-Ki Min | - |
dc.contributor.googleauthor | Deok-Gie Kim | - |
dc.contributor.googleauthor | Minyu Kang | - |
dc.contributor.googleauthor | Hwa-Hee Koh | - |
dc.contributor.googleauthor | Jae Geun Lee | - |
dc.contributor.googleauthor | Dong Jin Joo | - |
dc.contributor.googleauthor | Myoung Soo Kim | - |
dc.identifier.doi | 10.52604/alt.24.0004 | - |
dc.contributor.localId | A05303 | - |
dc.contributor.localId | A00424 | - |
dc.contributor.localId | A03068 | - |
dc.contributor.localId | A03948 | - |
dc.relation.journalcode | J04130 | - |
dc.identifier.eissn | 2765-6098 | - |
dc.subject.keyword | Carbapenem resistant | - |
dc.subject.keyword | Gram negative | - |
dc.subject.keyword | Liver transplantation | - |
dc.contributor.alternativeName | Kim, Deok Gie | - |
dc.contributor.affiliatedAuthor | 김덕기 | - |
dc.contributor.affiliatedAuthor | 김명수 | - |
dc.contributor.affiliatedAuthor | 이재근 | - |
dc.contributor.affiliatedAuthor | 주동진 | - |
dc.citation.volume | 4 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 16 | - |
dc.citation.endPage | 22 | - |
dc.identifier.bibliographicCitation | Annals of Liver Transplantation, Vol.4(1) : 16-22, 2024-05 | - |
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