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Tumoural Pellino-1 expression and Pellino-1-expressive cytotoxic T-cells are associated with poor prognosis in diffuse large B-cell lymphoma
DC Field | Value | Language |
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dc.contributor.author | 신수진 | - |
dc.date.accessioned | 2024-07-18T05:05:44Z | - |
dc.date.available | 2024-07-18T05:05:44Z | - |
dc.date.issued | 2024-04 | - |
dc.identifier.issn | 0031-3025 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/199998 | - |
dc.description.abstract | Pellino-1 plays a role in regulating inflammation and immune responses, and its effects on tumours are complex, with different outcomes reported in various studies. Additionally, the role of Pellino-1 in diffuse large B-cell lymphoma (DLBCL) has not been thoroughly investigated. We aimed to examine the expression of Pellino-1 in tumour cells and tumour-infiltrating lymphocytes (TILs) separately and identify the clinicopathological significance of Pellino-1 expression in DLBCL. We evaluated Pellino-1 expression in 104 patients with DLBCL. The density of specific cell types was quantitatively analysed using digital image analysis after a multiplex immunofluorescence staining with Pellino-1, CD20, CD8, FOXP3, and PD-1. Pellino-1 expression was mostly observed in CD20+ tumour cells and CD8+ TILs. The high CD8+/Pellino-1+ group was significantly associated with the non-GCB subtype and higher numbers of Foxp3+ T-cells. Patients with high CD20+/Pellino-1+ and high CD8+/Pellino-1+ cell densities had significantly shorter event-free survival (EFS) rates. The multivariate Cox-regression analysis showed that CD20+/Pellino-1+ cell density and CD8+/Pellino-1+ cell density were independent poor prognostic factors for EFS. Furthermore, patients with low densities of both CD20+/Pellino-1+ and CD8+/Pellino-1+ cells demonstrated a prognosis superior to that of patients with high Pellino-1+ cell densities, either alone or in combination. Additionally, the multivariate analysis demonstrated that the combination of CD20+/Pellino-1+ and CD8+/Pellino-1+ cell densities was an independent prognostic factor for EFS and overall survival. Pellino-1 expression was observed in both tumour cells and TILs, particularly in cytotoxic T-cells, and was correlated with poor outcomes in DLBCL. Thus, Pellino-1 might have an oncogenic effect on DLBCL and might be a potential target for improving cytotoxic T-cell activity. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | PATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | CD8-Positive T-Lymphocytes | - |
dc.subject.MESH | Forkhead Transcription Factors / metabolism | - |
dc.subject.MESH | Humans Lymphocytes, Tumor-Infiltrating / pathology | - |
dc.subject.MESH | Lymphoma, Large B-Cell, Diffuse* / metabolism | - |
dc.subject.MESH | Prognosis | - |
dc.title | Tumoural Pellino-1 expression and Pellino-1-expressive cytotoxic T-cells are associated with poor prognosis in diffuse large B-cell lymphoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Su-Jin Shin 1, Jiwon Ko 2, Hee Sang Hwang 3, Jooryung Huh 3, Chang-Woo Lee 4, Jin-Kwan Lee 4, Heounjeong Go | - |
dc.identifier.doi | 10.1016/j.pathol.2023.10.020 | - |
dc.contributor.localId | A04596 | - |
dc.relation.journalcode | J02471 | - |
dc.identifier.eissn | 1465-3931 | - |
dc.identifier.pmid | 38296676 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0031302524000047 | - |
dc.subject.keyword | Diffuse large B-cell lymphoma | - |
dc.subject.keyword | Pellino-1 | - |
dc.subject.keyword | cytotoxic T-cells | - |
dc.subject.keyword | multiplex immunofluorescence staining | - |
dc.contributor.alternativeName | Shin, Su Jin | - |
dc.contributor.affiliatedAuthor | 신수진 | - |
dc.citation.volume | 56 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 374 | - |
dc.citation.endPage | 381 | - |
dc.identifier.bibliographicCitation | PATHOLOGY, Vol.56(3) : 374-381, 2024-04 | - |
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