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Sex-related differences in presentation, treatment, and outcomes of Asian patients with atrial fibrillation: a report from the prospective APHRS-AF Registry
DC Field | Value | Language |
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dc.contributor.author | 엄재선 | - |
dc.date.accessioned | 2024-07-01T06:58:08Z | - |
dc.date.available | 2024-07-01T06:58:08Z | - |
dc.date.issued | 2023-12 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/199889 | - |
dc.description.abstract | We aimed to investigate the sex-related differences in the clinical course of patients with Atrial Fibrillation (AF) enrolled in the Asia-Pacific-Heart-Rhythm-Society Registry. Logistic regression was utilized to investigate the relationship between sex and oral anticoagulant, rhythm control strategies and the 1-year chance to maintain sinus rhythm. Cox-regression was utilized to assess the 1-year risk of all-cause, and cardiovascular death, thromboembolic events, acute coronary syndrome, heart failure, and major bleeding. In the whole cohort (4121 patients, 69 ± 12 years,34.3% female), females had different cardiovascular risk factors, clinical manifestations, and disease perceptions than men, with more advanced age (72 ± 11 vs 67 ± 12 years, p < 0.001) and dyslipidemia (36.7% vs 41.7%, p = 0.002). Coronary artery disease was more prevalent in males (21.1% vs 16.1%, p < 0.001) as well as the use of antiplatelet drugs. Females had a higher use of oral anticoagulant (84.9% vs 81.3%, p = 0.004) but this difference was non-significant after adjustment for confounders. On multivariable analyses, females were less often treated with rhythm control strategies (Odds Ratio [OR] 0.44,95% Confidence Interval [CI] 0.38-0.51) and were less likely to maintain sinus rhythm (OR 0.27, 95% CI 0.22-0.34) compared to males. Cox-regressions analysis showed no sex-related differences for the risk of death, cardiovascular, and bleeding. The clinical management of Asian AF patients should consider several sex-related differences. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Anticoagulants / therapeutic use | - |
dc.subject.MESH | Atrial Fibrillation* / complications | - |
dc.subject.MESH | Atrial Fibrillation* / drug therapy | - |
dc.subject.MESH | Atrial Fibrillation* / epidemiology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hemorrhage / chemically induced | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Registries | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Stroke* / etiology | - |
dc.title | Sex-related differences in presentation, treatment, and outcomes of Asian patients with atrial fibrillation: a report from the prospective APHRS-AF Registry | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Tommaso Bucci | - |
dc.contributor.googleauthor | Alena Shantsila | - |
dc.contributor.googleauthor | Giulio Francesco Romiti | - |
dc.contributor.googleauthor | Wee-Siong Teo | - |
dc.contributor.googleauthor | Hyung-Wook Park | - |
dc.contributor.googleauthor | Wataru Shimizu | - |
dc.contributor.googleauthor | Davide Antonio Mei | - |
dc.contributor.googleauthor | Hung-Fat Tse | - |
dc.contributor.googleauthor | Marco Proietti | - |
dc.contributor.googleauthor | Tze-Fan Chao | - |
dc.contributor.googleauthor | Gregory Y H Lip | - |
dc.contributor.googleauthor | Asia-Pacific Heart Rhythm Society Atrial Fibrillation Registry Investigators | - |
dc.identifier.doi | 10.1038/s41598-023-45345-3 | - |
dc.contributor.localId | A02337 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.contributor.alternativeName | Uhm, Jae Sun | - |
dc.contributor.affiliatedAuthor | 엄재선 | - |
dc.citation.volume | 13 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 18375 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.13(1) : 18375, 2023-12 | - |
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