Cited 9 times in
Clinical outcome of patients with mild pre-stroke morbidity following endovascular treatment: a HERMES substudy
DC Field | Value | Language |
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dc.contributor.author | 허지회 | - |
dc.date.accessioned | 2024-07-01T06:50:59Z | - |
dc.date.available | 2024-07-01T06:50:59Z | - |
dc.date.issued | 2023-03 | - |
dc.identifier.issn | 1759-8478 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/199831 | - |
dc.description.abstract | Background: Analyses of the effect of pre-stroke functional levels on the outcome of endovascular therapy (EVT) have focused on the course of patients with moderate to substantial pre-stroke disability. The effect of complete freedom from pre-existing disability (modified Rankin Scale (mRS) 0) versus predominantly mild pre-existing disability/symptoms (mRS 1-2) has not been well delineated. Methods: The HERMES meta-analysis pooled data from seven randomized trials that tested the efficacy of EVT. We tested for a multiplicative interaction effect of pre-stroke mRS on the relationship between treatment and outcomes. Ordinal regression was used to assess the association between EVT and 90-day mRS (primary outcome) in the subgroup of patients with pre-stroke mRS 1-2. Multivariable regression modeling was then used to test the effect of mild pre-stroke disability/symptoms on the primary and secondary outcomes (delta-mRS, mRS 0-2/5-6) compared with patients with pre-stroke mRS 0. Results: We included 1764 patients, of whom 199 (11.3%) had pre-stroke mRS 1-2. No interaction effect of pre-stroke mRS on the relationship between treatment and outcome was observed. Patients with pre-stroke mRS 1-2 had worse outcomes than those with pre-stroke mRS 0 (adjusted common OR (acOR) 0.53, 95% CI 0.40 to 0.70). Nonetheless, a significant benefit of EVT was observed within the mRS 1-2 subgroup (cOR 2.08, 95% CI 1.22 to 3.55). Conclusions: Patients asymptomatic/without disability prior to onset have better outcomes following EVT than patients with mild disability/symptoms. Patients with pre-stroke mRS 1-2, however, more often achieve good outcomes with EVT compared with conservative management. These findings indicate that mild pre-existing disability/symptoms influence patient prognosis after EVT but do not diminish the EVT treatment effect. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | BMJ Publishing Group | - |
dc.relation.isPartOf | JOURNAL OF NEUROINTERVENTIONAL SURGERY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Brain Ischemia* / therapy | - |
dc.subject.MESH | Endovascular Procedures* / adverse effects | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Stroke* / etiology | - |
dc.subject.MESH | Stroke* / surgery | - |
dc.subject.MESH | Thrombectomy / adverse effects | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Clinical outcome of patients with mild pre-stroke morbidity following endovascular treatment: a HERMES substudy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | Rosalie V McDonough | - |
dc.contributor.googleauthor | Johanna M Ospel | - |
dc.contributor.googleauthor | Charles B L M Majoie | - |
dc.contributor.googleauthor | Jeffrey L Saver | - |
dc.contributor.googleauthor | Philip White | - |
dc.contributor.googleauthor | Diederik W J Dippel | - |
dc.contributor.googleauthor | Scott B Brown | - |
dc.contributor.googleauthor | Andrew M Demchuk | - |
dc.contributor.googleauthor | Tudor G Jovin | - |
dc.contributor.googleauthor | Peter J Mitchell | - |
dc.contributor.googleauthor | Serge Bracard | - |
dc.contributor.googleauthor | Bruce C V Campbell | - |
dc.contributor.googleauthor | Keith W Muir | - |
dc.contributor.googleauthor | Michael D Hill | - |
dc.contributor.googleauthor | Francis Guillemin | - |
dc.contributor.googleauthor | Mayank Goyal | - |
dc.contributor.googleauthor | HERMES collaborators | - |
dc.identifier.doi | 10.1136/neurintsurg-2021-018428 | - |
dc.contributor.localId | A04369 | - |
dc.relation.journalcode | J02880 | - |
dc.identifier.eissn | 1759-8486 | - |
dc.identifier.pmid | 35210331 | - |
dc.identifier.url | https://jnis.bmj.com/content/15/3/214.long | - |
dc.subject.keyword | stroke | - |
dc.subject.keyword | thrombectomy | - |
dc.contributor.alternativeName | Heo, Ji Hoe | - |
dc.contributor.affiliatedAuthor | 허지회 | - |
dc.citation.volume | 15 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 214 | - |
dc.citation.endPage | 220 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEUROINTERVENTIONAL SURGERY, Vol.15(3) : 214-220, 2023-03 | - |
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