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Association between antidepressants and the risk of diabetic foot ulcers and amputation in antidepressant-naïve type 2 diabetes mellitus patients: A nested case-control study
DC Field | Value | Language |
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dc.contributor.author | 박은철 | - |
dc.contributor.author | 장석용 | - |
dc.contributor.author | 김진현 | - |
dc.contributor.author | 허경덕 | - |
dc.contributor.author | 김현규 | - |
dc.date.accessioned | 2024-06-14T02:51:45Z | - |
dc.date.available | 2024-06-14T02:51:45Z | - |
dc.date.issued | 2024-03 | - |
dc.identifier.issn | 0168-8227 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/199741 | - |
dc.description.abstract | Aims: Antidepressants are widely used by individuals with type 2 diabetes mellitus (T2DM). This study aimed to explore the correlation between antidepressant use, considering specific antidepressant subclasses or cumulative doses, and diabetic foot ulcer (DFU) risk. Methods: This nested case-control study was conducted using a representative population-based Korean cohort database from 2002 to 2019. Participants with DFUs were matched with participants without DFUs based on age, sex, date of T2DM diagnosis, and follow-up duration. In total, 791 DFUs and 3900 controls were included. The association between antidepressant use or cumulative dose of each antidepressant subclass, DFU risk and amputation risk was examined using a conditional logistic regression model. Results: Antidepressant ever-use was associated with an increased incidence of DFUs compared with non-use. Furthermore, an increase in DFU risk was evident with increasing cumulative antidepressant dosage, particularly among tricyclic antidepressant (TCA) ever-users and selective serotonin reuptake inhibitors (SSRIs) ever-users. Additionally, antidepressant ever-users displayed a higher risk of DFUs requiring amputation, which was consistently observed when the cumulative dosages of overall antidepressants and TCAs were considered. Conclusion: Caution is advised when administering TCAs and SSRIs in antidepressant-naïve T2DM patients to reduce DFU and the consequent amputation risk. © 2024 The Authors | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Elsevier Scientific Publishers | - |
dc.relation.isPartOf | DIABETES RESEARCH AND CLINICAL PRACTICE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Amputation, Surgical | - |
dc.subject.MESH | Antidepressive Agents / adverse effects | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Diabetes Mellitus* | - |
dc.subject.MESH | Diabetes Mellitus, Type 2* / complications | - |
dc.subject.MESH | Diabetes Mellitus, Type 2* / drug therapy | - |
dc.subject.MESH | Diabetes Mellitus, Type 2* / epidemiology | - |
dc.subject.MESH | Diabetic Foot* / drug therapy | - |
dc.subject.MESH | Diabetic Foot* / epidemiology | - |
dc.subject.MESH | Diabetic Foot* / surgery | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Selective Serotonin Reuptake Inhibitors / adverse effects | - |
dc.title | Association between antidepressants and the risk of diabetic foot ulcers and amputation in antidepressant-naïve type 2 diabetes mellitus patients: A nested case-control study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Preventive Medicine (예방의학교실) | - |
dc.contributor.googleauthor | Jinhyun Kim | - |
dc.contributor.googleauthor | Kyungduk Hurh | - |
dc.contributor.googleauthor | Seokmoon Han | - |
dc.contributor.googleauthor | Hyunkyu Kim | - |
dc.contributor.googleauthor | Eun-Cheol Park | - |
dc.contributor.googleauthor | Suk-Yong Jang | - |
dc.identifier.doi | 10.1016/j.diabres.2024.111591 | - |
dc.contributor.localId | A01618 | - |
dc.contributor.localId | A03432 | - |
dc.relation.journalcode | J00723 | - |
dc.identifier.eissn | 1872-8227 | - |
dc.identifier.pmid | 38403177 | - |
dc.subject.keyword | Amputation | - |
dc.subject.keyword | Antidepressant | - |
dc.subject.keyword | Diabetes mellitus | - |
dc.subject.keyword | Diabetic foot ulcer | - |
dc.subject.keyword | Nested case-control | - |
dc.contributor.alternativeName | Park, Eun-Chul | - |
dc.contributor.affiliatedAuthor | 박은철 | - |
dc.contributor.affiliatedAuthor | 장석용 | - |
dc.citation.volume | 209 | - |
dc.citation.startPage | 111591 | - |
dc.identifier.bibliographicCitation | DIABETES RESEARCH AND CLINICAL PRACTICE, Vol.209 : 111591, 2024-03 | - |
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