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Inhaled iloprost in off-pump coronary artery bypass surgery: a randomized controlled trial
DC Field | Value | Language |
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dc.contributor.author | 고서희 | - |
dc.contributor.author | 곽영란 | - |
dc.contributor.author | 소사라 | - |
dc.contributor.author | 송종욱 | - |
dc.contributor.author | 심재광 | - |
dc.date.accessioned | 2024-06-14T02:46:58Z | - |
dc.date.available | 2024-06-14T02:46:58Z | - |
dc.date.issued | 2024-04 | - |
dc.identifier.issn | 0832-610X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/199731 | - |
dc.description.abstract | Purpose : Mechanical cardiac constraint during off-pump coronary artery bypass surgery (OPCAB) causes right ventricle (RV) compression and increased pulmonary artery pressure (PAP), which may further compromise RV dysfunction. We aimed to assess the effect of inhaled iloprost, a potent selective pulmonary vasodilator, on the cardiac index (CI) during mechanical constraint. The secondary aim was to determine the resultant changes in the hemodynamic and respiratory parameters. Methods : A total of 100 adult patients with three-vessel coronary artery disease who had known risk factors for hemodynamic instability (congestive heart failure, mean PAP C 25 mm Hg, RV systolic pressure C 50 mm Hg on preoperative echocardiography, left ventricular ejection fraction\50%, myocardial infarction within one month of surgery, redo surgery, and left main disease) were enrolled in a randomized controlled trial. The patients were randomly allocated to the control or iloprost groups at a 1:1 ratio, in which saline and iloprost (20 lg) were inhaled for 15 min after internal mammary artery harvesting, respectively. Cardiac index was measured by pulmonary artery catheterization. Results : There were no significant intergroup differences in CI during grafting (P = 0.36). The mean PAP had a significant group-time interaction (P = 0.04) and was significantly lower in the iloprost group at circumflex grafting (mean [standard deviation], 26 [3] mm Hg vs 24 [3] mm Hg; P = 0.01). The remaining hemodynamic parameters were similar between the groups. Conclusion : Inhaled iloprost showed a neutral effect on hemodynamic parameters, including the CI and pulmonary vascular resistance index, during OPCAB. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer New York | - |
dc.relation.isPartOf | CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Coronary Artery Bypass, Off-Pump* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Iloprost* | - |
dc.subject.MESH | Stroke Volume | - |
dc.subject.MESH | Vasodilator Agents / pharmacology | - |
dc.subject.MESH | Ventricular Function, Left | - |
dc.title | Inhaled iloprost in off-pump coronary artery bypass surgery: a randomized controlled trial | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) | - |
dc.contributor.googleauthor | Seo Hee Ko | - |
dc.contributor.googleauthor | Jae-Kwang Shim | - |
dc.contributor.googleauthor | Jong-Wook Song | - |
dc.contributor.googleauthor | Sarah Soh | - |
dc.contributor.googleauthor | Young-Lan Kwak | - |
dc.identifier.doi | 10.1007/s12630-023-02672-3 | - |
dc.contributor.localId | A05083 | - |
dc.contributor.localId | A00172 | - |
dc.contributor.localId | A01960 | - |
dc.contributor.localId | A02060 | - |
dc.contributor.localId | A02205 | - |
dc.relation.journalcode | J00426 | - |
dc.identifier.eissn | 1496-8975 | - |
dc.identifier.pmid | 38148468 | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s12630-023-02672-3 | - |
dc.subject.keyword | cardiac index | - |
dc.subject.keyword | hemodynamic | - |
dc.subject.keyword | inhaled iloprost | - |
dc.subject.keyword | off-pump coronary artery bypass surgery | - |
dc.contributor.alternativeName | Ko, Seo Hee | - |
dc.contributor.affiliatedAuthor | 고서희 | - |
dc.contributor.affiliatedAuthor | 곽영란 | - |
dc.contributor.affiliatedAuthor | 소사라 | - |
dc.contributor.affiliatedAuthor | 송종욱 | - |
dc.contributor.affiliatedAuthor | 심재광 | - |
dc.citation.volume | 71 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 479 | - |
dc.citation.endPage | 489 | - |
dc.identifier.bibliographicCitation | CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE, Vol.71(4) : 479-489, 2024-04 | - |
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