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Multi-biomarker panel prediction model for diagnosis of pancreatic cancer

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dc.contributor.author강창무-
dc.date.accessioned2024-05-30T07:17:40Z-
dc.date.available2024-05-30T07:17:40Z-
dc.date.issued2023-01-
dc.identifier.issn1868-6974-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/199689-
dc.description.abstractBackground/Purpose The current study aimed to develop a prediction model using a multi-marker panel as a diagnostic screening tool for pancreatic ductal adenocarcinoma. Methods Multi-center cohort of 1991 blood samples were collected from January 2011 to September 2019, of which 609 were normal, 145 were other cancer (colorectal, thyroid, and breast cancer), 314 were pancreatic benign disease, and 923 were pancreatic ductal adenocarcinoma. The automated multi-biomarker Enzyme-Linked Immunosorbent Assay kit was developed using three potential biomarkers: LRG1, TTR, and CA 19-9. Using a logistic regression model on a training data set, the predicted values for pancreatic ductal adenocarcinoma were obtained, and the result was classification into one of the three risk groups: low, intermediate, and high. The five covariates used to create the model were sex, age, and three biomarkers. Results Participants were categorized into four groups as normal (n = 609), other cancer (n = 145), pancreatic benign disease (n = 314), and pancreatic ductal adenocarcinoma (n = 923). The normal, other cancer, and pancreatic benign disease groups were clubbed into the non-pancreatic ductal adenocarcinoma group (n = 1068). The positive and negative predictive value, sensitivity, and specificity were 94.12, 90.40, 93.81, and 90.86, respectively. Conclusions This study demonstrates a significant diagnostic performance of the multi-marker panel in distinguishing pancreatic ductal adenocarcinoma from normal and benign pancreatic disease states, as well as patients with other cancers.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley Japan-
dc.relation.isPartOfJOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdenocarcinoma* / diagnosis-
dc.subject.MESHAdenocarcinoma* / pathology-
dc.subject.MESHBiomarkers, Tumor-
dc.subject.MESHCarcinoma, Pancreatic Ductal* / pathology-
dc.subject.MESHHumans-
dc.subject.MESHPancreatic Diseases*-
dc.subject.MESHPancreatic Neoplasms* / pathology-
dc.titleMulti-biomarker panel prediction model for diagnosis of pancreatic cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorDoo-Ho Lee-
dc.contributor.googleauthorWoongchang Yoon-
dc.contributor.googleauthorAreum Lee-
dc.contributor.googleauthorYoungmin Han-
dc.contributor.googleauthorYoonhyeong Byun-
dc.contributor.googleauthorJae Seung Kang-
dc.contributor.googleauthorHongbeom Kim-
dc.contributor.googleauthorWooil Kwon-
dc.contributor.googleauthorYoung-Ah Suh-
dc.contributor.googleauthorYonghwan Choi-
dc.contributor.googleauthorJunghyun Namkung-
dc.contributor.googleauthorSangjo Han-
dc.contributor.googleauthorSung Gon Yi-
dc.contributor.googleauthorJin Seok Heo-
dc.contributor.googleauthorIn Woong Han-
dc.contributor.googleauthorJoon Oh Park-
dc.contributor.googleauthorJoo Kyung Park-
dc.contributor.googleauthorSong Cheol Kim-
dc.contributor.googleauthorEunsung Jun-
dc.contributor.googleauthorChang Moo Kang-
dc.contributor.googleauthorWoo Jin Lee-
dc.contributor.googleauthorHyeon Kook Lee-
dc.contributor.googleauthorHuisong Lee-
dc.contributor.googleauthorSeungyeoun Lee-
dc.contributor.googleauthorSeung-Yong Jeong-
dc.contributor.googleauthorKyu Eun Lee-
dc.contributor.googleauthorWonshik Han-
dc.contributor.googleauthorTaesung Park-
dc.contributor.googleauthorJin-Young Jang-
dc.identifier.doi10.1002/jhbp.986-
dc.contributor.localIdA00088-
dc.relation.journalcodeJ01440-
dc.identifier.eissn1868-6982-
dc.identifier.pmid33991409-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/10.1002/jhbp.986-
dc.subject.keywordbiomarker panel-
dc.subject.keyworddiagnosis-
dc.subject.keywordpancreatic ductal adenocarcinoma-
dc.subject.keywordscreening-
dc.subject.keywordtumor marker-
dc.contributor.alternativeNameKang, Chang Moo-
dc.contributor.affiliatedAuthor강창무-
dc.citation.volume30-
dc.citation.number1-
dc.citation.startPage122-
dc.citation.endPage132-
dc.identifier.bibliographicCitationJOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES, Vol.30(1) : 122-132, 2023-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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