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Cardioverter-defibrillator reduces mortality risk in eligible ischemic and non-ischemic cardiomyopathy patients: Sub-analysis of the multi- center Improve SCA study

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dc.contributor.author정보영-
dc.date.accessioned2024-05-30T07:12:14Z-
dc.date.available2024-05-30T07:12:14Z-
dc.date.issued2023-03-
dc.identifier.issn0019-4832-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/199635-
dc.description.abstractBackground & Objective: Despite the burden of sudden cardiac arrest (SCA) worldwide, implantable cardioverter-defibrillators (ICDs) are underutilized, particularly in Asia, Latin America, Eastern Europe, the Middle East, and Africa. The Improve SCA trial demonstrated that primary prevention (PP) patients in these regions benefit from an ICD or a cardiac resynchronization therapy defibrillator (CRT-D). We aimed to compare the rate of device therapy and mortality among ischemic and non-ischemic cardiomyopathy (ICM and NICM) PP patients who met guideline indications for ICD therapy and had an ICD/CRT-D implanted. Methods: Improve SCA was a prospective, non-randomized, non-blinded multicenter trial that enrolled patients from the above-mentioned regions. All-cause mortality and device therapy were examined by cardiomyopathy (ICM vs NICM) and implantation status. Cox proportional hazards methods were used, adjusting for factors affecting mortality risk. Results: Of 1848 PP NICM patients, 1007 (54.5%) received ICD/CRT-D, while 303 of 581 (52.1%) PP ICM patients received an ICD/CRT-D. The all-cause mortality rate at 3 years for NICM patients with and without an ICD/CRT-D was 13.1% and 18.3%, respectively (HR 0.51, 95% CI 0.38-0.68, p < 0.001). Similarly, all-cause mortality at 3 years in ICM patients was 13.8% in those with a device and 19.9% in those without an ICD/CRT-D (HR 0.54, 95% CI 0.33-.0.88, p = 0.011). The time to first device therapy, time to first shock, and time to first antitachycardia pacing (ATP) therapy were not significantly different between groups (p >= 0.263). Conclusions: In this large data set of patients with a guideline-based PP ICD indication, defibrillator device implantation conferred a significant mortality benefit in both NICM and ICM patients. The rate of appropriate device therapy was also similar in both groups.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfINDIAN HEART JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAged-
dc.subject.MESHCardiomyopathies* / mortality-
dc.subject.MESHCardiomyopathies* / therapy-
dc.subject.MESHDeath, Sudden, Cardiac / epidemiology-
dc.subject.MESHDeath, Sudden, Cardiac / prevention & control-
dc.subject.MESHDefibrillators, Implantable*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHIndia-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHProspective Studies-
dc.titleCardioverter-defibrillator reduces mortality risk in eligible ischemic and non-ischemic cardiomyopathy patients: Sub-analysis of the multi- center Improve SCA study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorBalbir Singh-
dc.contributor.googleauthorYu-Cheng Hsieh-
dc.contributor.googleauthorYen-Bin Liu-
dc.contributor.googleauthorKuo-Hung Lin-
dc.contributor.googleauthorBoyoung Joung-
dc.contributor.googleauthorDiego A Rodriguez-
dc.contributor.googleauthorAlexandr R Chasnoits-
dc.contributor.googleauthorDejia Huang-
dc.contributor.googleauthorShu Zhang-
dc.contributor.googleauthorJanet E O'Brien-
dc.contributor.googleauthorDaniel R Lexcen-
dc.contributor.googleauthorJeffrey Cerkvenik-
dc.contributor.googleauthorBrian Van Dorn-
dc.contributor.googleauthorChi-Keong Ching-
dc.identifier.doi10.1016/j.ihj.2023.01.010-
dc.contributor.localIdA03609-
dc.relation.journalcodeJ04594-
dc.identifier.eissn2213-3763-
dc.identifier.pmid36736459-
dc.subject.keywordHeart failure-
dc.subject.keywordImplantable cardioverter defibrillators-
dc.subject.keywordSudden cardiac arrest-
dc.subject.keywordSudden cardiac death-
dc.subject.keywordVentricular arrhythmias-
dc.contributor.alternativeNameJoung, Bo Young-
dc.contributor.affiliatedAuthor정보영-
dc.citation.volume75-
dc.citation.number2-
dc.citation.startPage115-
dc.citation.endPage121-
dc.identifier.bibliographicCitationINDIAN HEART JOURNAL, Vol.75(2) : 115-121, 2023-03-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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