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The IRON Study: Investigation of Robot-assisted Versus Open Nephron-sparing Surgery
DC Field | Value | Language |
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dc.contributor.author | 나군호 | - |
dc.date.accessioned | 2024-05-30T07:11:34Z | - |
dc.date.available | 2024-05-30T07:11:34Z | - |
dc.date.issued | 2023-03 | - |
dc.identifier.issn | 2666-1691 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/199628 | - |
dc.description.abstract | Background: Current literature does not provide large-scale data regarding clinical outcomes of robot-assisted (RAPN) versus open (OPN) partial nephrectomy. Moreover, data assessing predictors of long-term oncologic outcomes after RAPN are scarce.Objective: To compare perioperative, functional, and oncologic outcomes of RAPN versus OPN, and to investigate the predictors of oncologic outcomes after RAPN. Design, setting, and participants: This study included 3467 patients treated with OPN (n = 1063) or RAPN (n = 2404) for a single cT1-2N0M0 renal mass from 2004 to 2018 at nine high-volume European, North American, and Asian institutions.Outcome measurements and statistical analysis: The study outcomes were short-term postoperative, functional, and oncologic outcomes. Regression models investigated the effect of surgical approach (open vs Robot assisted) on study outcomes, and inter-action tests were used for subgroup analyses. Propensity score matching for demo-graphic and tumor characteristics was used in sensitivity analyses. Multivariable Cox-regression analyses identified predictors of oncologic outcomes after RAPN. Results and limitations: Baseline characteristics were similar between patients receiving RAPN and OPN, with only few differences. After adjusting for confound-ing, RAPN was associated with lower odds of intraoperative (odds ratio [OR]: 0.39, 95% confidence interval [CI]: 0.22, 0.68) and Clavien-Dindo >2 postoperative (OR: 0.29, 95% CI: 0.16, 0.50) complications (both p < 0.05). This association was not affected by comorbidities, tumor dimension, PADUA score, or preoperative renal function (all p > 0.05 on interaction tests). On multivariable analyses, we found no differences between the two techniques with respect to functional and onco-logic outcomes (all p > 0.05). Overall, there were 63 and 92 local recurrences and systemic progressions, respectively, with a median follow-up after surgery of 32 mo (interquartile range: 18, 60). Among patients receiving RAPN, we assessed pre-dictors of local recurrence and systemic progression with discrimination accuracy (ie, C-index) that ranged from 0.73 to 0.81.Conclusions: While cancer control and long-term renal function did not differ between RAPN and OPN, we found that the intra-and postoperative morbidity- especially in terms of complications-was lower after RAPN than after OPN. Our pre-dictive models allow surgeons to estimate the risk of adverse oncologic outcomes after RAPN, with relevant implications for preoperative counseling and follow-up after surgery.Patient summary: In this comparative study on robotic versus open partial nephrec-tomy, functional and oncologic outcomes were similar between the two techniques, with lower morbidity-especially in terms of complications-for robot-assisted sur-gery. The assessment of prognosticators for patients receiving robot-assisted partial nephrectomy may help in preoperative counseling and provides relevant data to tai-lor postoperative follow-up.(c) 2023 The Authors. Published by Elsevier B.V. on behalf of European Association of Urology. This is an open access article under the CC BY-NC-ND license (http://creative-commons.org/licenses/by-nc-nd/4.0/). | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.isPartOf | EUROPEAN UROLOGY OPEN SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | The IRON Study: Investigation of Robot-assisted Versus Open Nephron-sparing Surgery | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨의학교실) | - |
dc.contributor.googleauthor | Carlo Andrea Bravi | - |
dc.contributor.googleauthor | Giuseppe Rosiello | - |
dc.contributor.googleauthor | Elio Mazzone | - |
dc.contributor.googleauthor | Andrea Minervini | - |
dc.contributor.googleauthor | Andrea Mari | - |
dc.contributor.googleauthor | Fabrizio Di Maida | - |
dc.contributor.googleauthor | Karim Bensalah | - |
dc.contributor.googleauthor | Benoit Peyronnet | - |
dc.contributor.googleauthor | Zine-Eddine Khene | - |
dc.contributor.googleauthor | Riccardo Schiavina | - |
dc.contributor.googleauthor | Lorenzo Bianchi | - |
dc.contributor.googleauthor | Alexandre Mottrie | - |
dc.contributor.googleauthor | Geert De Naeyer | - |
dc.contributor.googleauthor | Alessandro Antonelli | - |
dc.contributor.googleauthor | Maria Furlan | - |
dc.contributor.googleauthor | Koon Ho Rha | - |
dc.contributor.googleauthor | Ahmad Almujalhem | - |
dc.contributor.googleauthor | Ithaar Derweesh | - |
dc.contributor.googleauthor | Aaronw Bradshaw | - |
dc.contributor.googleauthor | Jihak Kaouk | - |
dc.contributor.googleauthor | Guilherme Sawczyn | - |
dc.contributor.googleauthor | Riccardo Bertolo | - |
dc.contributor.googleauthor | Alberto Breda | - |
dc.contributor.googleauthor | Francesco Montorsi | - |
dc.contributor.googleauthor | Umberto Capitanio | - |
dc.contributor.googleauthor | Alessandro Larcher | - |
dc.contributor.googleauthor | Junior ERUS/Young Academic Urologist Working Group on Robot-assisted Surgery | - |
dc.identifier.doi | 10.1016/j.euros.2022.12.017 | - |
dc.contributor.localId | A01227 | - |
dc.relation.journalcode | J04284 | - |
dc.identifier.eissn | 2666-1683 | - |
dc.identifier.pmid | 36874602 | - |
dc.subject.keyword | Complications | - |
dc.subject.keyword | Open partial nephrectomy | - |
dc.subject.keyword | Perioperative outcomes | - |
dc.subject.keyword | Robot-assisted partial nephrectomy | - |
dc.subject.keyword | Robotic surgery | - |
dc.subject.keyword | Urological procedures | - |
dc.contributor.alternativeName | Rha, Koon Ho | - |
dc.contributor.affiliatedAuthor | 나군호 | - |
dc.citation.volume | 49 | - |
dc.citation.startPage | 71 | - |
dc.citation.endPage | 77 | - |
dc.identifier.bibliographicCitation | EUROPEAN UROLOGY OPEN SCIENCE, Vol.49 : 71-77, 2023-03 | - |
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