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Clinicopathologic characterization of cervical metastasis from an unknown primary tumor: a multicenter study in Korea

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dc.contributor.author윤선옥-
dc.date.accessioned2024-05-30T07:08:10Z-
dc.date.available2024-05-30T07:08:10Z-
dc.date.issued2023-05-
dc.identifier.issn2383-7837-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/199584-
dc.description.abstractBackground: Research regarding cervical metastasis from an unknown primary tumor (CUP) according to human papillomavirus (HPV) and Epstein-Barr virus (EBV) status in Korea has been sporadic and small-scale. This study aims to analyze and understand the charac-teristics of CUP in Korea according to viral and p16 and p53 status through a multicenter study. Methods: Ninety-five cases of CUP re-trieved from six hospitals in Korea between January 2006 and December 2016 were subjected to high-risk HPV detection (DNA in situ hybridization [ISH] or real-time polymerase chain reaction), EBV detection (ISH), and immunohistochemistry for p16 and p53. Results: CUP was HPV-related in 37 cases (38.9%), EBV-related in five cases (5.3%), and unrelated to HPV or EBV in 46 cases (48.4%). HPV-re-lated CUP cases had the best overall survival (OS) (p = .004). According to the multivariate analysis, virus-unrelated disease (p = .023) and longer smoking duration (p < .005) were prognostic factors for poor OS. Cystic change (p = .016) and basaloid pattern (p < .001) were more frequent in HPV-related cases, and lymphoepithelial lesion was frequent in EBV-related cases (p = .010). There was no significant association between viral status and p53 positivity (p = .341), smoking status (p = .728), or smoking duration (p = .187). Korean data differ from Western data in the absence of an association among HPV, p53 positivity, and smoking history. Conclusions: Virus-unrelated CUP in Korea had the highest frequency among all CUP cases. HPV-related CUP is similar to HPV-mediated oropharyngeal cancer and EBV-related CUP is similar to nasopharyngeal cancer in terms of characteristics, respectively.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherThe Korean Society of Pathologists-
dc.relation.isPartOfJOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleClinicopathologic characterization of cervical metastasis from an unknown primary tumor: a multicenter study in Korea-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학교실)-
dc.contributor.googleauthorMiseon Lee-
dc.contributor.googleauthorUiree Jo-
dc.contributor.googleauthorJoon Seon Song-
dc.contributor.googleauthorYoun Soo Lee-
dc.contributor.googleauthorChang Gok Woo-
dc.contributor.googleauthorDong-Hoon Kim-
dc.contributor.googleauthorJung Yeon Kim-
dc.contributor.googleauthorSun Och Yoon-
dc.contributor.googleauthorKyung-Ja Cho-
dc.identifier.doi10.4132/jptm.2023.04.12-
dc.contributor.localIdA02566-
dc.relation.journalcodeJ01680-
dc.identifier.eissn2383-7845-
dc.identifier.pmid37194150-
dc.subject.keywordEpstein-Barr virus infections-
dc.subject.keywordHuman papillomavirus virus-
dc.subject.keywordLymph node metastasis-
dc.subject.keywordUnknown primary neoplasms-
dc.contributor.alternativeNameYoon, Sun Och-
dc.contributor.affiliatedAuthor윤선옥-
dc.citation.volume57-
dc.citation.number3-
dc.citation.startPage166-
dc.citation.endPage177-
dc.identifier.bibliographicCitationJOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE, Vol.57(3) : 166-177, 2023-05-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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