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Long-term outcomes of endoscopic papillectomy for ampullary adenoma with high-grade dysplasia or adenocarcinoma: a propensity score-matched analysis
DC Field | Value | Language |
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dc.contributor.author | 이희승 | - |
dc.date.accessioned | 2024-05-30T07:07:14Z | - |
dc.date.available | 2024-05-30T07:07:14Z | - |
dc.date.issued | 2023-05 | - |
dc.identifier.issn | 0930-2794 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/199570 | - |
dc.description.abstract | Background Evidence of endoscopic papillectomy (EP) for ampullar adenoma with high-grade dysplasia (HGD) or adenocarcinoma is insufficient. Here we investigated the long-term outcomes of the advanced ampullary tumors treated by EP with careful surveillance comparing to subsequent surgery after EP. Methods Patients treated with EP for ampullary adenoma with HGD or adenocarcinoma from the multi-center retrospective Korean cohort of ampulla of Vater tumor were categorized into EP alone versus EP with subsequent surgery groups. The overall survival (OS) and recurrence-free survival (RFS) were analyzed for unmatched and matched cohorts using propensity score with nearest neighbor method. Results During a median 43.3 months of follow-up, 5-year OS was not significantly different between the EP alone and EP surgery groups (91.9% vs. 82.3%, P = 0.443 for unmatched cohort; 89.2% vs. 82.3%, P = 0.861 for matched cohort, respectively). Furthermore, 5-year RFS was not significantly different between the two groups (82.1% vs. 86.7%, P = 0.520 for unmatched cohort; 66.1% vs. 86.7%, P = 0.052 for matched cohort, respectively). However, the patients with positive both (lateral and deep) margins showed significantly poorer survival outcomes than those with negative margins within the EP alone group (P = 0.007). Conclusion EP alone with careful surveillance showed comparable survival outcomes to those of EP with subsequent surgery for ampullar HGD or adenocarcinoma. Resection margin status could be a parameter to determine whether to perform subsequent radical surgery after EP. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer | - |
dc.relation.isPartOf | SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adenocarcinoma* / pathology | - |
dc.subject.MESH | Adenocarcinoma* / surgery | - |
dc.subject.MESH | Adenoma* / pathology | - |
dc.subject.MESH | Ampulla of Vater* / pathology | - |
dc.subject.MESH | Ampulla of Vater* / surgery | - |
dc.subject.MESH | Common Bile Duct Neoplasms* / pathology | - |
dc.subject.MESH | Duodenal Neoplasms* / pathology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver Neoplasms* / pathology | - |
dc.subject.MESH | Margins of Excision | - |
dc.subject.MESH | Pancreatic Neoplasms* / pathology | - |
dc.subject.MESH | Propensity Score | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Long-term outcomes of endoscopic papillectomy for ampullary adenoma with high-grade dysplasia or adenocarcinoma: a propensity score-matched analysis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Seung Bae Yoon | - |
dc.contributor.googleauthor | Min Kyu Jung | - |
dc.contributor.googleauthor | Yoon Suk Lee | - |
dc.contributor.googleauthor | Joo Kyung Park | - |
dc.contributor.googleauthor | Dong Kee Jang | - |
dc.contributor.googleauthor | Jae Min Lee | - |
dc.contributor.googleauthor | Hee Seung Lee | - |
dc.contributor.googleauthor | Dong Woo Shin | - |
dc.contributor.googleauthor | Jong-Chan Lee | - |
dc.contributor.googleauthor | Jin-Hyeok Hwang | - |
dc.identifier.doi | 10.1007/s00464-022-09856-w | - |
dc.contributor.localId | A03349 | - |
dc.relation.journalcode | J02703 | - |
dc.identifier.eissn | 1432-2218 | - |
dc.identifier.pmid | 36587061 | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s00464-022-09856-w | - |
dc.subject.keyword | Adenocarcinoma | - |
dc.subject.keyword | Ampulla of Vater | - |
dc.subject.keyword | Carcinoma in situ | - |
dc.subject.keyword | Endoscopic mucosal resection | - |
dc.subject.keyword | Survival rate | - |
dc.contributor.alternativeName | Lee, Hee Seung | - |
dc.contributor.affiliatedAuthor | 이희승 | - |
dc.citation.volume | 37 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 3522 | - |
dc.citation.endPage | 3530 | - |
dc.identifier.bibliographicCitation | SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, Vol.37(5) : 3522-3530, 2023-05 | - |
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