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Net clinical benefit of oral anticoagulants in Korean atrial fibrillation patients with low to intermediate stroke risk: A report from the Clinical Survey on Stroke Prevention in patients with Atrial Fibrillation (CS-SPAF)
DC Field | Value | Language |
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dc.contributor.author | 김창수 | - |
dc.date.accessioned | 2024-05-30T07:06:23Z | - |
dc.date.available | 2024-05-30T07:06:23Z | - |
dc.date.issued | 2023-06 | - |
dc.identifier.issn | 1880-4276 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/199555 | - |
dc.description.abstract | BackgroundThe balance of stroke risk reduction and potential bleeding risk associated with antithrombotic treatment (ATT) remains unclear in atrial fibrillation (AF) at non-gender CHA(2)DS(2)-VASc scores 0-1. A net clinical benefit (NCB) analysis of ATT may guide stroke prevention strategies in AF with non-gender CHA(2)DS(2)-VASc scores 0-1. MethodsThis multi-center cohort study evaluated the clinical outcomes of treatment with a single antiplatelet (SAPT), vitamin K antagonist (VKA), and non-VKA oral anticoagulant (NOAC) in non-gender CHA(2)DS(2)-VASc score 0-1 and further stratified by biomarker-based ABCD score (Age [>= 60 years], B-type natriuretic peptide [BNP] or N-terminal pro-BNP [>= 300 pg/mL], creatinine clearance [<50 mL/min], and dimension of the left atrium [>= 45 mm]). The primary outcome was the NCB of ATT, including composite thrombotic events (ischemic stroke, systemic embolism, and myocardial infarction) and major bleeding events. ResultsWe included 2465 patients (age 56.2 +/- 9.5 years; female 27.0%) followed-up for 4.0 +/- 2.8 years, of whom 661 (26.8%) were treated with SAPT; 423 (17.2%) with VKA; and 1040 (42.2%) with NOAC. With detailed risk stratification using the ABCD score, NOAC showed a significant positive NCB compared with the other ATTs (SAPT vs. NOAC, NCB 2.01, 95% confidence interval [CI] 0.37-4.66; VKA vs. NOAC, NCB 2.38, 95% CI 0.56-5.40) in ABCD score >= 1. ATT failed to show a positive NCB in patients with truly low stroke risk (ABCD score = 0). ConclusionsIn the Korean AF cohort at non-gender CHA(2)DS(2)-VASc scores 0-1, NOAC showed significant NCB advantages over VKA or SAPT with ABCD score >= 1. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Japanese Society of Cardiac Pacing and Electrophysiology | - |
dc.relation.isPartOf | JOURNAL OF ARRHYTHMIA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Net clinical benefit of oral anticoagulants in Korean atrial fibrillation patients with low to intermediate stroke risk: A report from the Clinical Survey on Stroke Prevention in patients with Atrial Fibrillation (CS-SPAF) | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Preventive Medicine (예방의학교실) | - |
dc.contributor.googleauthor | Moonki Jung | - |
dc.contributor.googleauthor | Kyeongmin Byeon | - |
dc.contributor.googleauthor | Ki-Woon Kang | - |
dc.contributor.googleauthor | Wang-Soo Lee | - |
dc.contributor.googleauthor | Sang Wook Kim | - |
dc.contributor.googleauthor | Yae Min Park | - |
dc.contributor.googleauthor | You Mi Hwang | - |
dc.contributor.googleauthor | Sung Ho Lee | - |
dc.contributor.googleauthor | Eun-Sun Jin | - |
dc.contributor.googleauthor | Seung-Young Roh | - |
dc.contributor.googleauthor | Jin Seok Kim | - |
dc.contributor.googleauthor | Jinhee Ahn | - |
dc.contributor.googleauthor | So-Ryoung Lee | - |
dc.contributor.googleauthor | Eue-Keun Choi | - |
dc.contributor.googleauthor | Min-Soo Ahn | - |
dc.contributor.googleauthor | Eun Mi Lee | - |
dc.contributor.googleauthor | Hwan-Cheol Park | - |
dc.contributor.googleauthor | Ki Hong Lee | - |
dc.contributor.googleauthor | Min Kim | - |
dc.contributor.googleauthor | Joon Hyouk Choi | - |
dc.contributor.googleauthor | Jum Suk Ko | - |
dc.contributor.googleauthor | Jin Bae Kim | - |
dc.contributor.googleauthor | Changsoo Kim | - |
dc.contributor.googleauthor | Gregory Y H Lip | - |
dc.contributor.googleauthor | Seung Yong Shin | - |
dc.contributor.googleauthor | Clinical Survey on Stroke Prevention in patients with Atrial Fibrillation (CS‐SPAF) Investigators | - |
dc.identifier.doi | 10.1002/joa3.12840 | - |
dc.contributor.localId | A01042 | - |
dc.relation.journalcode | J03721 | - |
dc.identifier.eissn | 1883-2148 | - |
dc.identifier.pmid | 37324774 | - |
dc.subject.keyword | ABCD score | - |
dc.subject.keyword | antithrombotic treatment | - |
dc.subject.keyword | atrial fibrillation | - |
dc.subject.keyword | net clinical benefit | - |
dc.subject.keyword | non‐vitamin K antagonist oral anticoagulant | - |
dc.contributor.alternativeName | Kim, Chang Soo | - |
dc.contributor.affiliatedAuthor | 김창수 | - |
dc.citation.volume | 39 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 376 | - |
dc.citation.endPage | 387 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ARRHYTHMIA, Vol.39(3) : 376-387, 2023-06 | - |
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