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Discovery biomarker to optimize obeticholic acid treatment for non-alcoholic fatty liver disease

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dc.contributor.author오주희-
dc.date.accessioned2024-05-30T06:55:57Z-
dc.date.available2024-05-30T06:55:57Z-
dc.date.issued2023-08-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/199453-
dc.description.abstractThe response rate to obeticholic acid (OCA), a potential therapeutic agent for non-alcoholic fatty liver disease, is limited. This study demonstrated that upregulation of the alternative bile acid synthesis pathway increases the OCA treatment response rate. The hepatic transcriptome and bile acid metabolite profile analyses revealed that the alternative bile acid synthesis pathway (Cyp7b1 and muricholic acid) in the OCA-responder group were upregulated compared with those in the OCA-non-responder group. Intestinal microbiome analysis also revealed that the abundances of Bacteroidaceae, Parabacteroides, and Bacteroides, which were positively correlated with the alternative bile acid synthesis pathway, were higher in the OCA-responder group than in the non-responder group. Pre-study hepatic mRNA levels of Cyp8b1 (classic pathway) were downregulated in the OCA-responder group. The OCA response rate increased up to 80% in cases with a hepatic Cyp7b1/Cyp8b1 ratio = 5.0. Therefore, the OCA therapeutic response can be evaluated based on the Cyp7b1/Cyp8b1 ratio or the alternative/classic bile acid synthesis pathway activity.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherBioMed Central-
dc.relation.isPartOfBIOLOGY DIRECT-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHBile Acids and Salts-
dc.subject.MESHBiomarkers-
dc.subject.MESHHumans-
dc.subject.MESHNon-alcoholic Fatty Liver Disease* / drug therapy-
dc.subject.MESHSteroid 12-alpha-Hydroxylase-
dc.titleDiscovery biomarker to optimize obeticholic acid treatment for non-alcoholic fatty liver disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Obstetrics and Gynecology (산부인과학교실)-
dc.contributor.googleauthorSeung Min Lee-
dc.contributor.googleauthorDae Won Jun-
dc.contributor.googleauthorEileen Laurel Yoon-
dc.contributor.googleauthorJu Hee Oh-
dc.contributor.googleauthorYoon Jin Roh-
dc.contributor.googleauthorEun Jeoung Lee-
dc.contributor.googleauthorJi-Hee Shin-
dc.contributor.googleauthorYoung-Do Nam-
dc.contributor.googleauthorHyun Sung Kim-
dc.identifier.doi10.1186/s13062-023-00407-4-
dc.contributor.localIdA06529-
dc.relation.journalcodeJ04577-
dc.identifier.eissn1745-6150-
dc.identifier.pmid37626369-
dc.subject.keywordAlternative pathway-
dc.subject.keywordBile acid-
dc.subject.keywordBiomarker-
dc.subject.keywordMicrobiome-
dc.subject.keywordNon-alcoholic fatty liver-
dc.subject.keywordObeticholic acid-
dc.contributor.alternativeNameOh, Ju Hee-
dc.contributor.affiliatedAuthor오주희-
dc.citation.volume18-
dc.citation.number1-
dc.citation.startPage50-
dc.identifier.bibliographicCitationBIOLOGY DIRECT, Vol.18(1) : 50, 2023-08-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers

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