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Quality-adjusted survival in women with gynecologic malignancies receiving IMRT after surgery: A Ppatient Rreported Ooutcome study of NRG oncology's RTOG 1203
DC Field | Value | Language |
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dc.contributor.author | 김용배 | - |
dc.date.accessioned | 2024-05-30T06:54:48Z | - |
dc.date.available | 2024-05-30T06:54:48Z | - |
dc.date.issued | 2023-08 | - |
dc.identifier.issn | 0090-8258 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/199440 | - |
dc.description.abstract | Introduction. NRG/RTOG 1203 compared 3-D conformal radiotherapy (3D CRT) to intensity-modulated radiotherapy (IMRT) in patients with endometrial or cervical cancer requiring post-operative radiotherapy after hysterectomy. The purpose of this study was to report the first quality-adjusted survival analysis comparing the two treatments. Methods. NRG/RTOG 1203 randomized patients having undergone hysterectomy to either 3DCRT or IMRT. Stratification factors included RT dose, chemotherapy, and disease site. The EQ-5D, both index and visual analog scale (VAS), were obtained at baseline, 5 weeks after the start of RT, 4-6 weeks post RT and 1 and 3-years post RT. EQ-5D index and VAS scores along with quality-adjusted survival (QAS) were compared between treatment arms using the t-test at a two-sided significance level of 0.05.Results. NRG/RTOG 1203 enrolled 289 patients of which 236 consented to participate in the patient reported outcome (PRO) assessments. QAS was higher in women treated with IMRT, 1374 vs 1333 days (p = 0.5) com-pared to patients treated with 3DCRT, but this difference was not statistically different. Patients treated with IMRT had less of a decline in VAS score 5 weeks post RT, -5.04, compared to patients treated with 3DCRT, -7.48, although not statistically significant (p = 0.38).Conclusion. This is the first report of the use of the EQ-5D comparing two radiotherapy techniques in the treat-ment of gynecologic malignancies after surgery. While there were no significant differences in QAS and VAS scores between patients who received IMRT vs. 3DCRT, RTOG 1203 was not powered to show statistical differ-ences in these secondary endpoints.& COPY; 2023 Elsevier Inc. All rights reserved. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Academic Press | - |
dc.relation.isPartOf | GYNECOLOGIC ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genital Neoplasms, Female* / etiology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Radiotherapy Dosage | - |
dc.subject.MESH | Radiotherapy Planning, Computer-Assisted / methods | - |
dc.subject.MESH | Radiotherapy, Conformal* / adverse effects | - |
dc.subject.MESH | Radiotherapy, Intensity-Modulated* / methods | - |
dc.subject.MESH | Uterine Cervical Neoplasms* / etiology | - |
dc.subject.MESH | Uterine Cervical Neoplasms* / radiotherapy | - |
dc.subject.MESH | Uterine Cervical Neoplasms* / surgery | - |
dc.title | Quality-adjusted survival in women with gynecologic malignancies receiving IMRT after surgery: A Ppatient Rreported Ooutcome study of NRG oncology's RTOG 1203 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학교실) | - |
dc.contributor.googleauthor | Andre Konski | - |
dc.contributor.googleauthor | Snehal Deshmukh | - |
dc.contributor.googleauthor | Ann H Klopp | - |
dc.contributor.googleauthor | Anamaria R Yeung | - |
dc.contributor.googleauthor | Shannon N Westin | - |
dc.contributor.googleauthor | J Spencer Thompson | - |
dc.contributor.googleauthor | Desiree E Doncals | - |
dc.contributor.googleauthor | Guilherme H C Cantuaria | - |
dc.contributor.googleauthor | David P D'Souza | - |
dc.contributor.googleauthor | Amy Chang | - |
dc.contributor.googleauthor | Vijayananda Kundapur | - |
dc.contributor.googleauthor | Dasarahally S Mohan | - |
dc.contributor.googleauthor | Michael L Haas | - |
dc.contributor.googleauthor | Yong Bae Kim | - |
dc.contributor.googleauthor | Catherine L Ferguson | - |
dc.contributor.googleauthor | Stephanie L Pugh | - |
dc.contributor.googleauthor | Lisa A Kachnic | - |
dc.contributor.googleauthor | Deborah W Bruner | - |
dc.identifier.doi | 10.1016/j.ygyno.2023.05.074 | - |
dc.contributor.localId | A00744 | - |
dc.relation.journalcode | J00956 | - |
dc.identifier.eissn | 1095-6859 | - |
dc.identifier.pmid | 37393743 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S009082582300327X | - |
dc.subject.keyword | Cervical cancer | - |
dc.subject.keyword | Endometrial cancer | - |
dc.subject.keyword | Intensity modulated radiotherapy (IMRT) | - |
dc.subject.keyword | Patient reported outcomes | - |
dc.subject.keyword | Utilities | - |
dc.contributor.alternativeName | Kim, Yong Bae | - |
dc.contributor.affiliatedAuthor | 김용배 | - |
dc.citation.volume | 175 | - |
dc.citation.startPage | 176 | - |
dc.citation.endPage | 181 | - |
dc.identifier.bibliographicCitation | GYNECOLOGIC ONCOLOGY, Vol.175 : 176-181, 2023-08 | - |
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