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Chiral Cell Nanomechanics Originated in Clockwise/Counterclockwise Biofunctional Microarrays to Govern the Nuclear Mechanotransduction of Mesenchymal Stem Cells
DC Field | Value | Language |
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dc.contributor.author | 이규배 | - |
dc.date.accessioned | 2024-05-30T06:50:47Z | - |
dc.date.available | 2024-05-30T06:50:47Z | - |
dc.date.issued | 2023-10 | - |
dc.identifier.issn | 1944-8244 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/199377 | - |
dc.description.abstract | Cell chirality is extremely important for the evolution of cell morphogenesis to manipulate cell performance due to left-right asymmetry. Although chiral micro- and nanoscale biomaterials have been developed to regulate cell functions, how cell chirality affects cell nanomechanics to command nuclear mechanotransduction was ambiguous. In this study, chiral engineered microcircle arrays were prepared by photosensitive cross-linking synthesis on cell culture plates to control the clockwise/counterclockwise geometric topology of stem cells. Asymmetric focal adhesion and cytoskeleton structures could induce chiral cell nanomechanics measured by atomic force microscopy (AFM) nanoindentation in left-/right-handed stem cells. Cell nanomechanics could be enhanced when the construction of mature focal adhesion and the assembly of actin and myosin cytoskeletons were well organized in chiral engineered stem cells. Curvature angles had a negative effect on cell nanomechanics, while cell chirality did not change cytoskeletal mechanics. The biased cytoskeleton tension would engender different nuclear mechanotransductions by yes-associated protein (YAP) evaluation. The chiral stimuli were delivered into the nuclei to oversee nuclear behaviors. A strong cell modulus could activate high nuclear DNA synthesis activity by mechanotransduction. The results will bring the possibility of understanding the interplay of chiral cell nanomechanics and mechanotransduction in nanomedicines and biomaterials. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | American Chemical Society | - |
dc.relation.isPartOf | ACS APPLIED MATERIALS & INTERFACES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Biocompatible Materials / metabolism | - |
dc.subject.MESH | Biocompatible Materials / pharmacology | - |
dc.subject.MESH | Cytoskeleton / metabolism | - |
dc.subject.MESH | Mechanotransduction, Cellular* / physiology | - |
dc.subject.MESH | Mesenchymal Stem Cells* | - |
dc.subject.MESH | Stem Cells | - |
dc.title | Chiral Cell Nanomechanics Originated in Clockwise/Counterclockwise Biofunctional Microarrays to Govern the Nuclear Mechanotransduction of Mesenchymal Stem Cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | BioMedical Science Institute (의생명과학부) | - |
dc.contributor.googleauthor | Yongtao Wang | - |
dc.contributor.googleauthor | Xiaolan Tong | - |
dc.contributor.googleauthor | Xiaohui Shi | - |
dc.contributor.googleauthor | Tarun Keswani | - |
dc.contributor.googleauthor | Emeli Chatterjee | - |
dc.contributor.googleauthor | Lei Chen | - |
dc.contributor.googleauthor | Guoping Li | - |
dc.contributor.googleauthor | Kyubae Lee | - |
dc.contributor.googleauthor | Tao Guo | - |
dc.contributor.googleauthor | Yan Yu | - |
dc.identifier.doi | 10.1021/acsami.3c11188 | - |
dc.contributor.localId | A06468 | - |
dc.relation.journalcode | J00004 | - |
dc.identifier.eissn | 1944-8252 | - |
dc.identifier.pmid | 37812566 | - |
dc.identifier.url | https://pubs.acs.org/doi/10.1021/acsami.3c11188 | - |
dc.subject.keyword | DNA synthesis | - |
dc.subject.keyword | FA and cytoskeleton | - |
dc.subject.keyword | YAP mechanotransduction | - |
dc.subject.keyword | chiral nanomechanics | - |
dc.subject.keyword | engineered stem cells | - |
dc.contributor.alternativeName | Lee, Kyubae | - |
dc.contributor.affiliatedAuthor | 이규배 | - |
dc.citation.volume | 15 | - |
dc.citation.number | 41 | - |
dc.citation.startPage | 48038 | - |
dc.citation.endPage | 48049 | - |
dc.identifier.bibliographicCitation | ACS APPLIED MATERIALS & INTERFACES, Vol.15(41) : 48038-48049, 2023-10 | - |
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