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Impact of Tumor Size on the Difficulty of Laparoscopic Major Hepatectomies: An International Multicenter Study
DC Field | Value | Language |
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dc.contributor.author | 최기홍 | - |
dc.date.accessioned | 2024-05-30T06:50:16Z | - |
dc.date.available | 2024-05-30T06:50:16Z | - |
dc.date.issued | 2023-10 | - |
dc.identifier.issn | 1068-9265 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/199371 | - |
dc.description.abstract | IntroductionAlthough tumor size (TS) is known to affect surgical outcomes in laparoscopic liver resection (LLR), its impact on laparoscopic major hepatectomy (L-MH) is not well studied. The objectives of this study were to investigate the impact of TS on the perioperative outcomes of L-MH and to elucidate the optimal TS cutoff for stratifying the difficulty of L-MH.MethodsThis was a post-hoc analysis of 3008 patients who underwent L-MH at 48 international centers. A total 1396 patients met study criteria and were included. The impact of TS cutoffs was investigated by stratifying TS at each 10-mm interval. The optimal cutoffs were determined taking into consideration the number of endpoints which showed a statistically significant split around the cut-points of interest and the magnitude of relative risk after correction for multiple risk factors.ResultsWe identified 2 optimal TS cutoffs, 50 mm and 100 mm, which segregated L-MH into 3 groups. An increasing TS across these 3 groups (& LE; 50 mm, 51-100 mm, > 100 mm), was significantly associated with a higher open conversion rate (11.2%, 14.7%, 23.0%, P < 0.001), longer operating time (median, 340 min, 346 min, 365 min, P = 0.025), increased blood loss (median, 300 ml, ml, 400 ml, P = 0.002) and higher rate of intraoperative blood transfusion (13.1%, 15.9%, 27.6%, P < 0.001). Postoperative outcomes such as overall morbidity, major morbidity, and length of stay were comparable across the three groups.ConclusionIncreasing TS was associated with poorer intraoperative but not postoperative outcomes after L-MH. We determined 2 TS cutoffs (50 mm and 10 mm) which could optimally stratify the surgical difficulty of L-MH. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer | - |
dc.relation.isPartOf | ANNALS OF SURGICAL ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Hepatectomy / adverse effects | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Laparoscopy* / adverse effects | - |
dc.subject.MESH | Length of Stay | - |
dc.subject.MESH | Liver Neoplasms* / complications | - |
dc.subject.MESH | Operative Time | - |
dc.subject.MESH | Postoperative Complications / etiology | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | Impact of Tumor Size on the Difficulty of Laparoscopic Major Hepatectomies: An International Multicenter Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Yutaro Kato | - |
dc.contributor.googleauthor | Atsushi Sugioka | - |
dc.contributor.googleauthor | Masayuki Kojima | - |
dc.contributor.googleauthor | Nicholas L Syn | - |
dc.contributor.googleauthor | Wang Zhongkai | - |
dc.contributor.googleauthor | Rong Liu | - |
dc.contributor.googleauthor | Federica Cipriani | - |
dc.contributor.googleauthor | Thomas Armstrong | - |
dc.contributor.googleauthor | Davit L Aghayan | - |
dc.contributor.googleauthor | Tiing-Foong Siow | - |
dc.contributor.googleauthor | Chetana Lim | - |
dc.contributor.googleauthor | Olivier Scatton | - |
dc.contributor.googleauthor | Paulo Herman | - |
dc.contributor.googleauthor | Fabricio Ferreira Coelho | - |
dc.contributor.googleauthor | Marco V Marino | - |
dc.contributor.googleauthor | Vincenzo Mazzaferro | - |
dc.contributor.googleauthor | Adrian K H Chiow | - |
dc.contributor.googleauthor | Iswanto Sucandy | - |
dc.contributor.googleauthor | Arpad Ivanecz | - |
dc.contributor.googleauthor | Sung Hoon Choi | - |
dc.contributor.googleauthor | Jae Hoon Lee | - |
dc.contributor.googleauthor | Mikel Gastaca | - |
dc.contributor.googleauthor | Marco Vivarelli | - |
dc.contributor.googleauthor | Felice Giuliante | - |
dc.contributor.googleauthor | Bernardo Dalla Valle | - |
dc.contributor.googleauthor | Andrea Ruzzenente | - |
dc.contributor.googleauthor | Chee-Chien Yong | - |
dc.contributor.googleauthor | Constantino Fondevila | - |
dc.contributor.googleauthor | Mikhail Efanov | - |
dc.contributor.googleauthor | Fabrizio Di Benedetto | - |
dc.contributor.googleauthor | Andrea Belli | - |
dc.contributor.googleauthor | James O Park | - |
dc.contributor.googleauthor | Fernando Rotellar | - |
dc.contributor.googleauthor | Gi-Hong Choi | - |
dc.contributor.googleauthor | Ricardo Robles-Campos | - |
dc.contributor.googleauthor | Xiaoying Wang | - |
dc.contributor.googleauthor | Robert P Sutcliffe | - |
dc.contributor.googleauthor | Moritz Schmelzle | - |
dc.contributor.googleauthor | Johann Pratschke | - |
dc.contributor.googleauthor | Eric C H Lai | - |
dc.contributor.googleauthor | Charing C N Chong | - |
dc.contributor.googleauthor | Mathieu D'Hondt | - |
dc.contributor.googleauthor | Kazuteru Monden | - |
dc.contributor.googleauthor | Santiago Lopez-Ben | - |
dc.contributor.googleauthor | T Peter Kingham | - |
dc.contributor.googleauthor | Fabio Forchino | - |
dc.contributor.googleauthor | Alessandro Ferrero | - |
dc.contributor.googleauthor | Giuseppe Maria Ettorre | - |
dc.contributor.googleauthor | Giovanni Battista Levi Sandri | - |
dc.contributor.googleauthor | Franco Pascual | - |
dc.contributor.googleauthor | Daniel Cherqui | - |
dc.contributor.googleauthor | Olivier Soubrane | - |
dc.contributor.googleauthor | Go Wakabayashi | - |
dc.contributor.googleauthor | Roberto I Troisi | - |
dc.contributor.googleauthor | Tan-To Cheung | - |
dc.contributor.googleauthor | Zewei Chen | - |
dc.contributor.googleauthor | Mengqiu Yin | - |
dc.contributor.googleauthor | Mizelle D'Silva | - |
dc.contributor.googleauthor | Ho-Seong Han | - |
dc.contributor.googleauthor | Phan Phuoc Nghia | - |
dc.contributor.googleauthor | Tran Cong Duy Long | - |
dc.contributor.googleauthor | Bjørn Edwin | - |
dc.contributor.googleauthor | David Fuks | - |
dc.contributor.googleauthor | Kuo-Hsin Chen | - |
dc.contributor.googleauthor | Mohammad Abu Hilal | - |
dc.contributor.googleauthor | Luca Aldrighetti | - |
dc.contributor.googleauthor | Brian K P Goh | - |
dc.contributor.googleauthor | International Robotic and Laparoscopic Liver Resection Study Group Investigators | - |
dc.identifier.doi | 10.1245/s10434-023-13863-z | - |
dc.contributor.localId | A04046 | - |
dc.relation.journalcode | J00179 | - |
dc.identifier.eissn | 1534-4681 | - |
dc.identifier.pmid | 37505351 | - |
dc.identifier.url | https://link.springer.com/article/10.1245/s10434-023-13863-z | - |
dc.subject.keyword | Difficulty | - |
dc.subject.keyword | Laparoscopic liver resection | - |
dc.subject.keyword | Major hepatectomy | - |
dc.subject.keyword | Minimally invasive liver | - |
dc.subject.keyword | Size | - |
dc.contributor.alternativeName | Choi, Gi Hong | - |
dc.contributor.affiliatedAuthor | 최기홍 | - |
dc.citation.volume | 30 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 6628 | - |
dc.citation.endPage | 6636 | - |
dc.identifier.bibliographicCitation | ANNALS OF SURGICAL ONCOLOGY, Vol.30(11) : 6628-6636, 2023-10 | - |
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