Cited 0 times in
Genetic and epigenetic aspects of the KISS1 and KISS1R genes in pubertal development and central precocious puberty
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권아름 | - |
dc.date.accessioned | 2024-05-30T06:41:56Z | - |
dc.date.available | 2024-05-30T06:41:56Z | - |
dc.date.issued | 2023-12 | - |
dc.identifier.issn | 2508-7940 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/199290 | - |
dc.description.abstract | The onset of puberty is a pivotal developmental milestone, and the release of gonadotropin-releasing hormone (GnRH) and luteinizing hormone is a key factor in the initiation of puberty. Both kisspeptin and its receptor (KISS1) and KISS1 receptor (KISS1R) play significant roles in regulating GnRH release, and consequently, the initiation of puberty. Central precocious puberty (CPP) is a condition in which the development of puberty is driven by the premature activation of the hypothalamic-pituitary-gonadal axis. In girls, CPP is primarily idiopathic, and genetic and epigenetic aspects of KISS1 and KISS1R have been implicated in its etiology. This review aimed to provide an overview of the current knowledge regarding mutations and polymorphisms in KISS1 and KISS1R associated with CPP. Additionally, this study provides a comprehensive review of the epigenetic regulation of the KISS1 gene in the context of puberty onset and CPP. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Sungkyunkwan University School of Medicine | - |
dc.relation.isPartOf | PRECISION AND FUTURE MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Genetic and epigenetic aspects of the KISS1 and KISS1R genes in pubertal development and central precocious puberty | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학교실) | - |
dc.contributor.googleauthor | Ahreum Kwon | - |
dc.identifier.doi | 10.23838/pfm.2023.00156 | - |
dc.contributor.localId | A00228 | - |
dc.relation.journalcode | J04090 | - |
dc.identifier.eissn | 2508-7959 | - |
dc.contributor.alternativeName | Kwon, Ah Reum | - |
dc.contributor.affiliatedAuthor | 권아름 | - |
dc.citation.volume | 7 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 137 | - |
dc.citation.endPage | 146 | - |
dc.identifier.bibliographicCitation | PRECISION AND FUTURE MEDICINE, Vol.7(4) : 137-146, 2023-12 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.