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Impact of Lactate Dehydrogenase and Hemoglobin Levels on Clinical Outcomes in Patients With Paroxysmal Nocturnal Hemoglobinuria: Results From the National Korean PNH Registry
DC Field | Value | Language |
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dc.contributor.author | 김진석 | - |
dc.date.accessioned | 2024-05-23T03:30:46Z | - |
dc.date.available | 2024-05-23T03:30:46Z | - |
dc.date.issued | 2024-03 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/199246 | - |
dc.description.abstract | Background: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disorder caused by uncontrolled terminal complement activation, which leads to intravascular hemolysis (IVH), thromboembolism (TE), renal failure, and premature mortality. Methods: We performed a secondary analysis of data collected from patients enrolled in the Korean National PNH Registry to assess the relative importance of risk factors, specifically lactate dehydrogenase (LDH) and hemoglobin (Hb), in predicting the incidence of TE, impaired renal function, and death in complement inhibitor-naïve patients with PNH. Results: Multivariate regression modeling indicated that LDH ≥ 1.5 × upper limit of normal (ULN), male sex, and pain were associated with increased risk of TE (P = 0.016, 0.045, and 0.033, respectively), hemoglobinuria and pain were associated with an increased risk of impaired renal function (P = 0.034 and 0.022, respectively), and TE was associated with an increased incidence of death (P < 0.001). Hb < 8 g/dL was not a predictor of TE, impaired renal function, or death in multivariate regression analyses. Standardized mortality ratio analysis indicated that LDH ≥ 1.5 × ULN (P < 0.001), Hb < 8 g/dL (P < 0.001), and Hb ≥ 8 g/dL (P = 0.004) were all risk factors for death; in contrast, patients with LDH < 1.5 × ULN had similar mortality to the general population. Conclusion: In complement inhibitor-naïve patients with PNH, LDH ≥ 1.5 × ULN was a significant predictor of TE, and TE was a significant predictor of death. Hb was not a significant predictor of TE, impaired renal function, or death. Therefore, controlling IVH will improve clinical outcomes for patients with PNH. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | 대한의학회(The Korean Academy of Medical Sciences) | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Complement Inactivating Agents | - |
dc.subject.MESH | Hemoglobinuria, Paroxysmal* / complications | - |
dc.subject.MESH | Hemoglobinuria, Paroxysmal* / diagnosis | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | L-Lactate Dehydrogenase | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Pain | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Thromboembolism* | - |
dc.title | Impact of Lactate Dehydrogenase and Hemoglobin Levels on Clinical Outcomes in Patients With Paroxysmal Nocturnal Hemoglobinuria: Results From the National Korean PNH Registry | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Jun Ho Jang | - |
dc.contributor.googleauthor | Jin Seok Kim | - |
dc.contributor.googleauthor | Cindy Thiow Koon Lim | - |
dc.contributor.googleauthor | Nora J Kleinman | - |
dc.contributor.googleauthor | Karl-Johan Myren | - |
dc.contributor.googleauthor | Alice Wang | - |
dc.contributor.googleauthor | Yogesh Patel | - |
dc.contributor.googleauthor | Jong Wook Lee | - |
dc.identifier.doi | 10.3346/jkms.2024.39.e81 | - |
dc.contributor.localId | A01017 | - |
dc.relation.journalcode | J01517 | - |
dc.identifier.eissn | 1598-6357 | - |
dc.identifier.pmid | 38442722 | - |
dc.subject.keyword | Anemia | - |
dc.subject.keyword | Hemolysis | - |
dc.subject.keyword | Mortality | - |
dc.subject.keyword | Paroxysmal Nocturnal Hemoglobinuria | - |
dc.contributor.alternativeName | Kim, Jin Seok | - |
dc.contributor.affiliatedAuthor | 김진석 | - |
dc.citation.volume | 39 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | e81 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.39(8) : e81, 2024-03 | - |
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