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Visualizing cancer-originating acetate uptake through monocarboxylate transporter 1 in reactive astrocytes in the glioblastoma tumor microenvironment

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dc.contributor.author강석구-
dc.contributor.author김세훈-
dc.contributor.author김지수-
dc.contributor.author윤미진-
dc.contributor.author장종희-
dc.contributor.author전중현-
dc.contributor.author한경석-
dc.date.accessioned2024-05-23T03:27:58Z-
dc.date.available2024-05-23T03:27:58Z-
dc.date.issued2024-05-
dc.identifier.issn1522-8517-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/199234-
dc.description.abstractBackground : Reactive astrogliosis is a hallmark of various brain pathologies, including neurodegenerative diseases and glioblastomas. However, the specific intermediate metabolites contributing to reactive astrogliosis remain unknown. This study investigated how glioblastomas induce reactive astrogliosis in the neighboring microenvironment and explores 11C-acetate PET as an imaging technique for detecting reactive astrogliosis. Methods : Through in vitro, mouse models, and human tissue experiments, we examined the association between elevated 11C-acetate uptake and reactive astrogliosis in gliomas. We explored acetate from glioblastoma cells, which triggers reactive astrogliosis in neighboring astrocytes by upregulating MAO-B and MCT1 expression. We evaluated the presence of cancer stem cells in the reactive astrogliosis region of glioblastomas and assessed the correlation between the volume of 11C-acetate uptake beyond MRI and prognosis. Results : Elevated 11C-acetate uptake is associated with reactive astrogliosis and astrocytic MCT1 in the periphery of glioblastomas in human tissues and mouse models. Glioblastoma cells exhibit increased acetate production as a result of glucose metabolism, with subsequent secretion of acetate. Acetate derived from glioblastoma cells induces reactive astrogliosis in neighboring astrocytes by increasing the expression of MAO-B and MCT1. We found cancer stem cells within the reactive astrogliosis at the tumor periphery. Consequently, a larger volume of 11C-acetate uptake beyond contrast-enhanced MRI was associated with worse prognosis. Conclusion : Our results highlight the role of acetate derived from glioblastoma cells in inducing reactive astrogliosis and underscore the potential value of 11C-acetate PET as an imaging technique for detecting reactive astrogliosis, offering important implications for the diagnosis and treatment of glioblastomas.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherOxford University Press-
dc.relation.isPartOfNEURO-ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAcetates* / metabolism-
dc.subject.MESHAnimals-
dc.subject.MESHAstrocytes* / metabolism-
dc.subject.MESHAstrocytes* / pathology-
dc.subject.MESHBrain Neoplasms* / diagnostic imaging-
dc.subject.MESHBrain Neoplasms* / metabolism-
dc.subject.MESHBrain Neoplasms* / pathology-
dc.subject.MESHGlioblastoma* / diagnostic imaging-
dc.subject.MESHGlioblastoma* / metabolism-
dc.subject.MESHGlioblastoma* / pathology-
dc.subject.MESHGliosis / metabolism-
dc.subject.MESHGliosis / pathology-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMonocarboxylic Acid Transporters* / metabolism-
dc.subject.MESHPositron-Emission Tomography* / methods-
dc.subject.MESHPrognosis-
dc.subject.MESHSymporters* / metabolism-
dc.subject.MESHTumor Microenvironment*-
dc.titleVisualizing cancer-originating acetate uptake through monocarboxylate transporter 1 in reactive astrocytes in the glioblastoma tumor microenvironment-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurosurgery (신경외과학교실)-
dc.contributor.googleauthorDongwoo Kim 1-
dc.contributor.googleauthorHae Young Ko 1-
dc.contributor.googleauthorJee-In Chung 1-
dc.contributor.googleauthorYongmin Mason Park 2 3-
dc.contributor.googleauthorSangwon Lee 1-
dc.contributor.googleauthorSeon Yoo Kim-
dc.contributor.googleauthorJisu Kim-
dc.contributor.googleauthorJoong-Hyun Chun-
dc.contributor.googleauthorKyung-Seok Han-
dc.contributor.googleauthorMisu Lee-
dc.contributor.googleauthorYeon Ha Ju-
dc.contributor.googleauthorSun Jun Park-
dc.contributor.googleauthorKi Duk Park-
dc.contributor.googleauthorMin-Ho Nam-
dc.contributor.googleauthorSe Hoon Kim-
dc.contributor.googleauthorJin-Kyoung Shim-
dc.contributor.googleauthorYoungjoo Park-
dc.contributor.googleauthorHyunkeong Lim-
dc.contributor.googleauthorJaekyung Park-
dc.contributor.googleauthorGwan-Ho Lee-
dc.contributor.googleauthorHyunjin Kim-
dc.contributor.googleauthorSuhyun Kim-
dc.contributor.googleauthorUiyeol Park-
dc.contributor.googleauthorHoon Ryu-
dc.contributor.googleauthorSo Yun Lee-
dc.contributor.googleauthorSunghyouk Park-
dc.contributor.googleauthorSeok-Gu Kang-
dc.contributor.googleauthorJong Hee Chang-
dc.contributor.googleauthorC Justin Lee-
dc.contributor.googleauthorMijin Yun-
dc.identifier.doi10.1093/neuonc/noad243-
dc.contributor.localIdA00036-
dc.contributor.localIdA00610-
dc.contributor.localIdA00969-
dc.contributor.localIdA02550-
dc.contributor.localIdA03470-
dc.contributor.localIdA05406-
dc.contributor.localIdA04264-
dc.relation.journalcodeJ02346-
dc.identifier.eissn1523-5866-
dc.identifier.pmid38085571-
dc.identifier.urlhttps://academic.oup.com/neuro-oncology/article/26/5/843/7471337-
dc.subject.keywordPET imaging-
dc.subject.keywordacetate-
dc.subject.keywordglioblastoma-
dc.subject.keywordmonocarboxylate transporter 1-
dc.subject.keywordreactive astrogliosis-
dc.contributor.alternativeNameKang, Seok Gu-
dc.contributor.affiliatedAuthor강석구-
dc.contributor.affiliatedAuthor김세훈-
dc.contributor.affiliatedAuthor김지수-
dc.contributor.affiliatedAuthor윤미진-
dc.contributor.affiliatedAuthor장종희-
dc.contributor.affiliatedAuthor전중현-
dc.contributor.affiliatedAuthor한경석-
dc.citation.volume26-
dc.citation.number5-
dc.citation.startPage843-
dc.citation.endPage857-
dc.identifier.bibliographicCitationNEURO-ONCOLOGY, Vol.26(5) : 843-857, 2024-05-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

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