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Prediction of effectiveness of universal rotavirus vaccination in Southwestern Vietnam based on a dynamic mathematical model
DC Field | Value | Language |
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dc.contributor.author | 강지만 | - |
dc.contributor.author | 안종균 | - |
dc.contributor.author | 염준섭 | - |
dc.date.accessioned | 2024-05-23T03:11:48Z | - |
dc.date.available | 2024-05-23T03:11:48Z | - |
dc.date.issued | 2024-02 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/199171 | - |
dc.description.abstract | Vaccinating young children against rotavirus (RV) is a promising preventive strategy against rotavirus gastroenteritis (RVGE). We evaluated the relative risk reduction of RVGE induced by universal vaccination in Vietnam through dynamic model analysis. We developed an age-stratified dynamic Vaccinated-Susceptible-Infectious-Recovered-Susceptible model to analyze RV transmission and assess vaccine effectiveness (VE). We assumed 3 different vaccine efficacies: 55%, 70%, and 85%. For model calibration, we used a database of patients under 5 years of age admitted to Ho Chi Minh No.1 Hospital with RVGE between January 2013 and December 2018. Assuming a vaccination rate of 95%, the number of RVGE hospitalizations after 5 years from universal RV vaccination decreased from 92,502 cases to 45,626 with 85% efficacy, to 54,576 cases with 70% efficacy, and to 63,209 cases with 55% efficacy. Additionally, RVGE hospitalizations after 10 years decreased from 177,950 to 89,517 with 85% efficacy and to 121,832 cases with 55% efficacy. The relative risk reductions of RVGE after 10 years were 49.7% with 85% efficacy, 40.6% with 70% efficacy, and 31.5% with 55% efficacy. The VE was 1.10 times (95% CI, 1.01–1.22) higher in the 4-months to 1-year-old age group than in the other age groups (P = 0.038), when applying 85% efficacy with 95% coverage. In conclusion, despite its relatively lower efficacy compared to high-income countries, RV vaccination remains an effective intervention in Southwestern Vietnam. In particular, implementing universal RV vaccination with higher coverage would result in a decrease in RVGE hospitalizations among Vietnamese children under 5 years of age. © The Author(s) 2024. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Gastroenteritis* / epidemiology | - |
dc.subject.MESH | Gastroenteritis* / prevention & control | - |
dc.subject.MESH | Hospitalization | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Infant | - |
dc.subject.MESH | Models, Theoretical | - |
dc.subject.MESH | Rotavirus Infections* / epidemiology | - |
dc.subject.MESH | Rotavirus Infections* / prevention & control | - |
dc.subject.MESH | Rotavirus Vaccines* / therapeutic use | - |
dc.subject.MESH | Rotavirus* | - |
dc.subject.MESH | Vaccination | - |
dc.subject.MESH | Vietnam / epidemiology | - |
dc.title | Prediction of effectiveness of universal rotavirus vaccination in Southwestern Vietnam based on a dynamic mathematical model | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학교실) | - |
dc.contributor.googleauthor | Taeyong Lee | - |
dc.contributor.googleauthor | Ji-Man Kang | - |
dc.contributor.googleauthor | Jong Gyun Ahn | - |
dc.contributor.googleauthor | Dung Thi Thuy Truong | - |
dc.contributor.googleauthor | Thuong Vu Nguyen | - |
dc.contributor.googleauthor | Thang Vinh Ho | - |
dc.contributor.googleauthor | Ha Thi Thanh Ton | - |
dc.contributor.googleauthor | Phuc Le Hoang | - |
dc.contributor.googleauthor | Min Young Kim | - |
dc.contributor.googleauthor | Joon-Sup Yeom | - |
dc.contributor.googleauthor | Jeehyun Lee | - |
dc.identifier.doi | 10.1038/s41598-024-54775-6 | - |
dc.contributor.localId | A05720 | - |
dc.contributor.localId | A02261 | - |
dc.contributor.localId | A02353 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 38383679 | - |
dc.subject.keyword | Dynamic model | - |
dc.subject.keyword | Mathematical model | - |
dc.subject.keyword | Rotavirus | - |
dc.subject.keyword | Vaccine | - |
dc.subject.keyword | Vaccine effectiveness | - |
dc.subject.keyword | Vietnam | - |
dc.contributor.alternativeName | Kang, Ji-Man | - |
dc.contributor.affiliatedAuthor | 강지만 | - |
dc.contributor.affiliatedAuthor | 안종균 | - |
dc.contributor.affiliatedAuthor | 염준섭 | - |
dc.citation.volume | 14 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 4273 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.14(1) : 4273, 2024-02 | - |
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