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Interleukin-2/anti-interleukin-2 immune complex attenuates cold ischemia-reperfusion injury after kidney transplantation by increasing renal regulatory T cells
DC Field | Value | Language |
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dc.contributor.author | 김범석 | - |
dc.contributor.author | 김형우 | - |
dc.contributor.author | 양재석 | - |
dc.date.accessioned | 2024-05-23T02:50:26Z | - |
dc.date.available | 2024-05-23T02:50:26Z | - |
dc.date.issued | 2024-03 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/199095 | - |
dc.description.abstract | BackgroundCold ischemia-reperfusion injury (IRI) is an unavoidable complication of kidney transplantation. We investigated the role of regulatory T cells (Treg) in cold IRI and whether the interleukin (IL)-2/anti-IL-2 antibody complex (IL-2C) can ameliorate cold IRI.MethodsWe developed a cold IRI mouse model using kidney transplantation and analyzed the IL-2C impact on cold IRI in acute, subacute and chronic phases.ResultsTreg transfer attenuated cold IRI, while Treg depletion aggravated cold IRI. Next, IL-2C administration prior to IRI mitigated acute renal function decline, renal tissue damage and apoptosis and inhibited infiltration of effector cells into kidneys and pro-inflammatory cytokine expression on day 1 after IRI. On day 7 after IRI, IL-2C promoted renal regeneration and reduced subacute renal damage. Furthermore, on day 28 following IRI, IL-2C inhibited chronic fibrosis. IL-2C decreased reactive oxygen species-mediated injury and improved antioxidant function. When IL-2C was administered following IRI, it also increased renal regeneration with Treg infiltration and suppressed renal fibrosis. In contrast, Treg depletion in the presence of IL-2C eliminated the positive effects of IL-2C on IRI.ConclusionTregs protect kidneys from cold IRI and IL-2C inhibited cold IRI by increasing the renal Tregs, suggesting a potential of IL-2C in treating cold IRI.Key Points Interleukin (IL)-2/anti-IL-2 antibody complex attenuated acute renal injury, facilitated subacute renal regeneration and suppressed chronic renal fibrosis after cold ischemia-reperfusion injury (IRI) by increasing the renal Tregs. IL-2/anti-IL-2 antibody complex decreased reactive oxygen species-mediated injury and improved antioxidant function. This study suggests the therapeutic potential of the IL-2/anti-IL-2 antibody complex in kidney transplantation-associated cold IR.,Interleukin (IL)-2/anti-IL-2 antibody complex attenuated acute renal injury, facilitated subacute renal regeneration and suppressed chronic renal fibrosis after cold ischemia-reperfusion injury (IRI) by increasing the renal Tregs. IL-2/anti-IL-2 antibody complex decreased reactive oxygen species-mediated injury and improved antioxidant function. This study suggests the therapeutic potential of the IL-2/anti-IL-2 antibody complex in kidney transplantation-associated cold IRI. image, | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | CLINICAL AND TRANSLATIONAL MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Acute Kidney Injury* / drug therapy | - |
dc.subject.MESH | Acute Kidney Injury* / etiology | - |
dc.subject.MESH | Acute Kidney Injury* / metabolism | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antigen-Antibody Complex | - |
dc.subject.MESH | Antioxidants / pharmacology | - |
dc.subject.MESH | Fibrosis | - |
dc.subject.MESH | Interleukin-2 / metabolism | - |
dc.subject.MESH | Kidney | - |
dc.subject.MESH | Kidney Transplantation* / adverse effects | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Reactive Oxygen Species / metabolism | - |
dc.subject.MESH | Reperfusion Injury* / drug therapy | - |
dc.subject.MESH | Reperfusion Injury* / metabolism | - |
dc.subject.MESH | T-Lymphocytes, Regulatory | - |
dc.title | Interleukin-2/anti-interleukin-2 immune complex attenuates cold ischemia-reperfusion injury after kidney transplantation by increasing renal regulatory T cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Joon Young Jang | - |
dc.contributor.googleauthor | Hyung Woo Kim | - |
dc.contributor.googleauthor | Ji-Jing Yan | - |
dc.contributor.googleauthor | Tae Kyeom Kang | - |
dc.contributor.googleauthor | Wook-Bin Lee | - |
dc.contributor.googleauthor | Beom Seok Kim | - |
dc.contributor.googleauthor | Jaeseok Yang | - |
dc.identifier.doi | 10.1002/ctm2.1631 | - |
dc.contributor.localId | A00488 | - |
dc.contributor.localId | A01151 | - |
dc.contributor.localId | A06130 | - |
dc.relation.journalcode | J04562 | - |
dc.identifier.eissn | 2304-6767 | - |
dc.identifier.pmid | 38504554 | - |
dc.subject.keyword | IL-2/anti-IL-2 immune complex | - |
dc.subject.keyword | cold ischemia-reperfusion injury | - |
dc.subject.keyword | kidney transplantation | - |
dc.subject.keyword | regulatory T cells | - |
dc.contributor.alternativeName | Kim, Beom Seok | - |
dc.contributor.affiliatedAuthor | 김범석 | - |
dc.contributor.affiliatedAuthor | 김형우 | - |
dc.contributor.affiliatedAuthor | 양재석 | - |
dc.citation.volume | 14 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | e1631 | - |
dc.identifier.bibliographicCitation | CLINICAL AND TRANSLATIONAL MEDICINE, Vol.14(3) : e1631, 2024-03 | - |
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