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Effect of 5% albumin on endothelial glycocalyx degradation during off-pump coronary artery bypass
DC Field | Value | Language |
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dc.contributor.author | 곽영란 | - |
dc.contributor.author | 소사라 | - |
dc.contributor.author | 송종욱 | - |
dc.contributor.author | 심재광 | - |
dc.date.accessioned | 2024-04-11T06:29:42Z | - |
dc.date.available | 2024-04-11T06:29:42Z | - |
dc.date.issued | 2024-03 | - |
dc.identifier.issn | 0832-610X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/198804 | - |
dc.description.abstract | Purpose: The integrity of the endothelial glycocalyx (EG), a critical player in vascular homeostasis, reportedly influences the outcomes of critically ill patients. We investigated the effect of 5% albumin, which preserved EG integrity in preclinical studies, vs balanced crystalloid solution on EG degradation in patients undergoing off-pump coronary surgery. Methods: Patients were randomized to receive either 5% albumin (N = 51) or balanced crystalloid solution (Plasma-Lyte [Baxter Incorporated, Seoul, Republic of Korea]; N = 53) for intravenous volume replacement during surgery (double-blinded). The primary outcome was plasma syndecan-1 concentration, a marker of EG degradation, measured after anesthetic induction (baseline), completion of grafting, and sternal closure. Secondary outcomes were atrial natriuretic peptide (ANP), tumour necrosis factor (TNF)-α, soluble thrombomodulin, and perioperative fluid balance. Results: The mean (standard deviation) fluid requirements were 833 (270) mL and 1,323 (492) mL in the albumin and Plasma-Lyte group, respectively (mean difference, -489 mL; 95% confidence interval [CI], -643 to -335; P < 0.001). Plasma syndecan-1 concentration increased after completion of grafting (median difference, 116 ng·mL-1; 95% CI, 67 to 184; P < 0.001) and sternal closure (median difference, 57 ng·mL-1; 95% CI, 36 to 80; P < 0.001) compared with those at baseline, without any intergroup differences. Atrial natriuretic peptide, TNF-α, and soluble thrombomodulin concentrations were similar between the two groups. The amount of chest tube drainage was greater in the albumin group than that in the Plasma-Lyte group (median difference, 190 mL; 95% CI, 18 to 276; P = 0.03). Conclusion: Off-pump coronary surgery was associated with significant EG degradation. Yet, intraoperative fluid therapy with 5% albumin could not ameliorate EG degradation when compared with balanced crystalloid solution. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer New York | - |
dc.relation.isPartOf | CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Albumins | - |
dc.subject.MESH | Atrial Natriuretic Factor / metabolism | - |
dc.subject.MESH | Coronary Artery Bypass, Off-Pump* / adverse effects | - |
dc.subject.MESH | Crystalloid Solutions | - |
dc.subject.MESH | Gluconates | - |
dc.subject.MESH | Glycocalyx / metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Magnesium Chloride | - |
dc.subject.MESH | Potassium Chloride | - |
dc.subject.MESH | Sodium Acetate | - |
dc.subject.MESH | Sodium Chloride | - |
dc.subject.MESH | Syndecan-1 / metabolism | - |
dc.subject.MESH | Thrombomodulin / metabolism | - |
dc.title | Effect of 5% albumin on endothelial glycocalyx degradation during off-pump coronary artery bypass | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) | - |
dc.contributor.googleauthor | Zhengyu Nan | - |
dc.contributor.googleauthor | Sarah Soh | - |
dc.contributor.googleauthor | Jae-Kwang Shim | - |
dc.contributor.googleauthor | Hye Bin Kim | - |
dc.contributor.googleauthor | Yun Seok Yang | - |
dc.contributor.googleauthor | Young Lan Kwak | - |
dc.contributor.googleauthor | Jong Wook Song | - |
dc.identifier.doi | 10.1007/s12630-023-02652-7 | - |
dc.contributor.localId | A00172 | - |
dc.contributor.localId | A01960 | - |
dc.contributor.localId | A02060 | - |
dc.contributor.localId | A02205 | - |
dc.relation.journalcode | J00426 | - |
dc.identifier.eissn | 1496-8975 | - |
dc.identifier.pmid | 37989943 | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s12630-023-02652-7 | - |
dc.subject.keyword | albumin | - |
dc.subject.keyword | cardiac surgery | - |
dc.subject.keyword | fluid resuscitation | - |
dc.subject.keyword | glycocalyx | - |
dc.subject.keyword | syndecan-1 | - |
dc.subject.keyword | vascular homeostasis | - |
dc.contributor.alternativeName | Kwak, Young Lan | - |
dc.contributor.affiliatedAuthor | 곽영란 | - |
dc.contributor.affiliatedAuthor | 소사라 | - |
dc.contributor.affiliatedAuthor | 송종욱 | - |
dc.contributor.affiliatedAuthor | 심재광 | - |
dc.citation.volume | 71 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 244 | - |
dc.citation.endPage | 253 | - |
dc.identifier.bibliographicCitation | CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE, Vol.71(2) : 244-253, 2024-03 | - |
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