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Abemaciclib plus fulvestrant in East Asian women with HR+, HER2-advanced breast cancer: Overall survival from MONARCH 2

Authors
 Masakazu Toi  ;  Chiun-Sheng Huang  ;  Young-Hyuck Im  ;  Joohyuk Sohn  ;  Wei Zhang  ;  Sachi Sakaguchi  ;  Nadine Haddad  ;  Gertjan van Hal  ;  George W Sledge Jr 
Citation
 CANCER SCIENCE, Vol.114(1) : 221-226, 2023-01 
Journal Title
CANCER SCIENCE
ISSN
 1347-9032 
Issue Date
2023-01
MeSH
Aminopyridines ; Antineoplastic Combined Chemotherapy Protocols / therapeutic use ; Breast Neoplasms* / metabolism ; East Asian People ; Female ; Fulvestrant ; Humans ; Receptor, ErbB-2 / genetics ; Receptor, ErbB-2 / metabolism
Keywords
East Asia ; abemaciclib ; breast cancer ; cyclin-dependent kinase inhibitor ; metastatic
Abstract
MONARCH 2 is a global, randomized, double-blind, phase 3 study of abemaciclib/placebo + fulvestrant in patients with hormone receptor positive, human epidermal growth factor receptor 2-negative advanced breast cancer. The East Asian population comprised 212 (31.7%) of the 669 intent-to-treat population in the MONARCH 2 trial. Consistent with the primary analysis, this subpopulation analysis of East Asian patients indicated progression-free survival benefit in the abemaciclib arm. The median overall survival was not reached in the abemaciclib arm and was 48.9 months in the placebo arm (hazard ratio 0.80; 95% confidence interval 0.52-1.24; p = 0.377). In addition, other efficacy endpoints, including time to chemotherapy, chemotherapy free survival, and time to second disease progression, indicated benefit in the abemaciclib arm. This analysis found no new safety concerns with longer follow-up. These findings support the positive benefit-risk balance of the MONARCH 2 regimen in East Asian patients with hormone receptor positive, human epidermal growth factor receptor 2-negative advanced breast cancer.
Files in This Item:
T999202770.pdf Download
DOI
10.1111/cas.15600
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Sohn, Joo Hyuk(손주혁) ORCID logo https://orcid.org/0000-0002-2303-2764
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/198772
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