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Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy versus R0 resection for resectable colorectal cancer with peritoneal metastases and low peritoneal cancer index scores: a collaborative observational study from Korea and Japan

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dc.contributor.author박은정-
dc.contributor.author백승혁-
dc.date.accessioned2024-03-22T07:15:40Z-
dc.date.available2024-03-22T07:15:40Z-
dc.date.issued2024-01-
dc.identifier.issn1743-9191-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/198716-
dc.description.abstractBackground: The benefits of hyperthermic intraperitoneal chemotherapy (HIPEC) after cytoreductive surgery (CRS) for colorectal cancer with peritoneal metastasis (CPM) remain controversial. R0 resection without peritoneal stripping might be as effective as CRS plus HIPEC. The authors aimed to compare the long-term oncological outcomes of patients with CPM and peritoneal cancer index (PCI) scores less than or equal to 6 who underwent R0 resection in Japan with those who underwent CRS plus HIPEC in Korea.Materials and methods: This international, retrospective cohort study was conducted in Korea and Japan using a prospectively collected clinical database. Patients who underwent surgery from July 2014 to December 2021 for CPM with a PCI score of less than or equal to 6 and completeness of the cytoreduction score-0 were included. The primary outcome was relapse-free survival (RFS), and the secondary outcomes were overall survival, peritoneal RFS (PRFS), and postoperative outcomes.Results: The 3-year RFS was significantly longer in the CRS+HIPEC group than in the R0 resection group: 35.9% versus 6.9% (P<0.001); 31.0% versus 6.7% (P=0.040) after propensity score matching. The median PRFS was significantly longer in the CRS+HIPEC group than in the R0 resection group: 24.5 months versus 17.2 months (P=0.017). The 3-year overall survival and postoperative complications did not significantly differ between the two groups.Conclusions: RFS and PRFS rates were significantly prolonged after CRS plus HIPEC, whereas postoperative complications and length of hospital stay were not increased. Therefore, curative CRS plus HIPEC may be considered a treatment strategy for selected patients with resectable CPM and low PCI scores.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF SURGERY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAntineoplastic Combined Chemotherapy Protocols / therapeutic use-
dc.subject.MESHColorectal Neoplasms* / pathology-
dc.subject.MESHCombined Modality Therapy-
dc.subject.MESHCytoreduction Surgical Procedures / adverse effects-
dc.subject.MESHHumans-
dc.subject.MESHHyperthermia, Induced*-
dc.subject.MESHHyperthermic Intraperitoneal Chemotherapy-
dc.subject.MESHJapan-
dc.subject.MESHNeoplasm Recurrence, Local / pathology-
dc.subject.MESHPeritoneal Neoplasms* / drug therapy-
dc.subject.MESHPeritoneal Neoplasms* / surgery-
dc.subject.MESHPostoperative Complications / drug therapy-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSurvival Rate-
dc.titleCytoreductive surgery plus hyperthermic intraperitoneal chemotherapy versus R0 resection for resectable colorectal cancer with peritoneal metastases and low peritoneal cancer index scores: a collaborative observational study from Korea and Japan-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorDaichi Kitaguchi-
dc.contributor.googleauthorEun Jung Park-
dc.contributor.googleauthorSeung Hyuk Baik-
dc.contributor.googleauthorShoma Sasaki-
dc.contributor.googleauthorYuichiro Tsukada-
dc.contributor.googleauthorMasaaki Ito-
dc.identifier.doi10.1097/JS9.0000000000000809-
dc.contributor.localIdA04572-
dc.contributor.localIdA01827-
dc.relation.journalcodeJ01162-
dc.identifier.eissn1743-9159-
dc.identifier.pmid37800569-
dc.contributor.alternativeNamePark, Eun Jung-
dc.contributor.affiliatedAuthor박은정-
dc.contributor.affiliatedAuthor백승혁-
dc.citation.volume110-
dc.citation.number1-
dc.citation.startPage45-
dc.citation.endPage52-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF SURGERY, Vol.110(1) : 45-52, 2024-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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