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Impact of sensitization and ABO blood types on the opportunity of deceased-donor kidney transplantation with prolonged waiting time
DC Field | Value | Language |
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dc.contributor.author | 김범석 | - |
dc.contributor.author | 양재석 | - |
dc.contributor.author | 이정은 | - |
dc.contributor.author | 이진형 | - |
dc.date.accessioned | 2024-03-22T07:12:49Z | - |
dc.date.available | 2024-03-22T07:12:49Z | - |
dc.date.issued | 2024-02 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/198707 | - |
dc.description.abstract | The waiting time to deceased-donor kidney transplantation (DDKT) is long in Asian countries. We investigated the impact of sensitization and ABO blood type (ABO) on DDKT opportunity using two Korean cohorts: a hospital cohort from two centers and a national database. The impact of panel reactive antibody (PRA) based on the maximal PRA% and ABO on DDKT accessibility was analyzed using a competing risks regression model. In the hospital cohort (n = 4722), 88.2%, 8.7%, and 3.1% of patients belonged to < 80%, 80-99%, and ≥ 99% PRA groups, respectively, and 61.1%, 11.6%, and 27.3% belonged to A or B, AB, and O blood types, respectively. When PRA and ABO were combined, PRA < 80%/A or B and 80 ≤ PRA < 99%/AB had fewer DDKT opportunities (median, 12 years; subdistribution hazard ratio [sHR], 0.71) compared with PRA < 80%/AB (median, 11 years). Also, PRA < 80%/O, 80 ≤ PRA < 99%/A or B, and PRA ≥ 99%/AB had a much lower DDKT opportunity (median, 13 years; sHR, 0.49). Furthermore, 80 ≤ PRA < 99%/O and PRA ≥ 99%/non-AB had the lowest DDKT opportunity (sHR, 0.28). We found similar results in the national cohort (n = 18,974). In conclusion, an integrated priority system for PRA and ABO is needed to reduce the inequity in DDKT opportunities, particularly in areas with prolonged waiting times. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Blood Grouping and Crossmatching | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kidney | - |
dc.subject.MESH | Kidney Transplantation* / methods | - |
dc.subject.MESH | Tissue Donors | - |
dc.subject.MESH | Waiting Lists | - |
dc.title | Impact of sensitization and ABO blood types on the opportunity of deceased-donor kidney transplantation with prolonged waiting time | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Jin Hyeog Lee | - |
dc.contributor.googleauthor | Tai Yeon Koo | - |
dc.contributor.googleauthor | Jung Eun Lee | - |
dc.contributor.googleauthor | Kook Hwan Oh | - |
dc.contributor.googleauthor | Beom Seok Kim | - |
dc.contributor.googleauthor | Jaeseok Yang | - |
dc.identifier.doi | 10.1038/s41598-024-53157-2 | - |
dc.contributor.localId | A00488 | - |
dc.contributor.localId | A06130 | - |
dc.contributor.localId | A03119 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 38302674 | - |
dc.contributor.alternativeName | Kim, Beom Seok | - |
dc.contributor.affiliatedAuthor | 김범석 | - |
dc.contributor.affiliatedAuthor | 양재석 | - |
dc.contributor.affiliatedAuthor | 이정은 | - |
dc.citation.volume | 14 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 2635 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.14(1) : 2635, 2024-02 | - |
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