Cited 0 times in
Alleviation of peripheral sensitization by quadriceps insertion of cog polydioxanone filaments in knee osteoarthritis rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이배환 | - |
dc.contributor.author | 차명훈 | - |
dc.date.accessioned | 2024-03-22T07:11:41Z | - |
dc.date.available | 2024-03-22T07:11:41Z | - |
dc.date.issued | 2024-02 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/198702 | - |
dc.description.abstract | A recently established therapeutic strategy, involving the insertion of biodegradable cog polydioxanone filaments into the quadriceps muscles using the Muscle Enhancement and Support Therapy (MEST) device, has demonstrated significant efficacy in alleviating knee osteoarthritis (OA) pain. This study investigated changes in peripheral sensitization as the potential mechanism underlying MEST-induced pain relief in monoiodoacetate (MIA) induced OA rats. The results revealed that MEST treatment potently reduces MIA-induced sensitization of L3/L4 dorsal root ganglion (DRG) neurons, the primary nociceptor pathway for the knee joint. This reduction in DRG sensitization, as elucidated by voltage-sensitive dye imaging, is accompanied by a diminished overexpression of TRPA1 and NaV1.7, key nociceptor receptors involved in mechanical pain perception. Importantly, these observed alterations strongly correlate with a decrease in mechanically-evoked pain behaviors, providing compelling neurophysiological evidence that MEST treatment alleviates OA pain by suppressing peripheral sensitization. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Ganglia, Spinal / metabolism | - |
dc.subject.MESH | Osteoarthritis, Knee* / metabolism | - |
dc.subject.MESH | Pain / drug therapy | - |
dc.subject.MESH | Pain / metabolism | - |
dc.subject.MESH | Polydioxanone / metabolism | - |
dc.subject.MESH | Quadriceps Muscle / metabolism | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.title | Alleviation of peripheral sensitization by quadriceps insertion of cog polydioxanone filaments in knee osteoarthritis rats | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Physiology (생리학교실) | - |
dc.contributor.googleauthor | Myeounghoon Cha | - |
dc.contributor.googleauthor | Heyji Bak | - |
dc.contributor.googleauthor | Bae Hwan Lee | - |
dc.contributor.googleauthor | Jun Ho Jang | - |
dc.identifier.doi | 10.1016/j.bbrc.2024.149549 | - |
dc.contributor.localId | A02791 | - |
dc.contributor.localId | A03994 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.pmid | 38266311 | - |
dc.subject.keyword | NaV1.7 | - |
dc.subject.keyword | Nociceptor | - |
dc.subject.keyword | Osteoarthritis | - |
dc.subject.keyword | Pain | - |
dc.subject.keyword | Quadriceps | - |
dc.subject.keyword | TRPA1 | - |
dc.contributor.alternativeName | Lee, Bae Hwan | - |
dc.contributor.affiliatedAuthor | 이배환 | - |
dc.contributor.affiliatedAuthor | 차명훈 | - |
dc.citation.volume | 698 | - |
dc.citation.startPage | 149549 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.698 : 149549, 2024-02 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.