Cited 1 times in
Shift in risk factors for mortality by period of the bloodstream infection timeline
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김도균 | - |
dc.contributor.author | 송영구 | - |
dc.contributor.author | 정석훈 | - |
dc.contributor.author | 최민혁 | - |
dc.date.accessioned | 2024-03-22T07:06:56Z | - |
dc.date.available | 2024-03-22T07:06:56Z | - |
dc.date.issued | 2024-02 | - |
dc.identifier.issn | 1684-1182 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/198683 | - |
dc.description.abstract | Background: This study was designed to determine changes in risk factors on the prognosis of patients during each period of the bloodstream infection (BSI) timeline. Methods: Through an integrated study of multivariable regressions with machine learning techniques, the risk factors for mortality during each period of BSI were analyzed. Results: A total of 302,303 inpatients who underwent blood cultures during 2011-2021 were enrolled. More than 8 % of BSI cases progressed to subsequent BSI, and risk factors were identified as gut colonization with vancomycin-resistant enterococci (aOR 1.82; 95 % CI 1.47-2.24), intensive care unit admission (aOR 3.37; 95 % CI 3.35-4.28), and current cancer chemotherapy (aOR 1.54; 95 % CI 1.36-1.74). The mean SOFA score of the deceased patients during the first 7 days was 10.6 (SD 4.3), which was significantly higher than those on days 8-30 (7.0 ± 4.2) and after Day 30 (4.0 ± 3.5). BSIs caused by Acinetobacter baumannii and Candida albicans were more likely to result in deaths of patients for all time periods (all, P < 0.001). BSIs caused by Enterococcus faecalis and Enterococcus faecium were associated with a poor outcome in the period after Day 30 (both, P < 0.001). Nonsusceptible phenotypes to β-lactam/β-lactamase inhibitors of Escherichia coli and Klebsiella pneumoniae influenced the prognoses of patients with BSI in terms of high mortality rates during both days 8-30 and after Day 30. Conclusion: Influence of microbiological factors on mortality, including BSI-causative microorganisms and their major antimicrobial resistance, was emphasized in both periods of days 8-30 and after Day 30. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English, Chinese | - |
dc.publisher | Elsevier for the Taiwan Society of Microbiology | - |
dc.relation.isPartOf | JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Bacteremia* / microbiology | - |
dc.subject.MESH | Escherichia coli | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Sepsis* / complications | - |
dc.subject.MESH | Vancomycin-Resistant Enterococci* | - |
dc.title | Shift in risk factors for mortality by period of the bloodstream infection timeline | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.googleauthor | Min Hyuk Choi | - |
dc.contributor.googleauthor | Dokyun Kim | - |
dc.contributor.googleauthor | Jihyun Kim | - |
dc.contributor.googleauthor | Young Goo Song | - |
dc.contributor.googleauthor | Seok Hoon Jeong | - |
dc.identifier.doi | 10.1016/j.jmii.2023.11.008 | - |
dc.contributor.localId | A04891 | - |
dc.contributor.localId | A02037 | - |
dc.contributor.localId | A03619 | - |
dc.relation.journalcode | J01595 | - |
dc.identifier.eissn | 1995-9133 | - |
dc.identifier.pmid | 38092626 | - |
dc.contributor.alternativeName | Kim, Dokyun | - |
dc.contributor.affiliatedAuthor | 김도균 | - |
dc.contributor.affiliatedAuthor | 송영구 | - |
dc.contributor.affiliatedAuthor | 정석훈 | - |
dc.citation.volume | 57 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 97 | - |
dc.citation.endPage | 106 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION, Vol.57(1) : 97-106, 2024-02 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.