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Clinical association of health-related quality of life and mortality in an antineutrophil cytoplasmic antibody-associated vasculitis cohort
DC Field | Value | Language |
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dc.contributor.author | 박용범 | - |
dc.contributor.author | 안성수 | - |
dc.contributor.author | 이상원 | - |
dc.date.accessioned | 2024-03-22T06:30:22Z | - |
dc.date.available | 2024-03-22T06:30:22Z | - |
dc.date.issued | 2024-02 | - |
dc.identifier.issn | 0049-0172 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/198561 | - |
dc.description.abstract | Objectives: To evaluate the association between health-related quality of life (HRQoL) and mortality in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). Methods: We searched patients with AAV assessed for HRQoL at initial diagnosis using Short Form 36 (SF-36). Relationships between SF-36 physical component summary (PCS) and mental component summary (MCS) scales and variables were estimated using Pearson’s correlation analysis. Contal’s and O’Quigley’s methods were used to determine optimal SF-36 PCS cut-off for predicting all-cause mortality. The Cox proportional hazards model and inverse probability of treatment weighting (IPTW) analysis were used to ascertain prognostic implications of SF-36 scales and mortality. Results: The median SF-36 PCS and MCS values of the 189 patients were 47.5 and 53.3, respectively, and 21 (11.1%) patients (microscopic polyangiitis [MPA], n=15; granulomatosis with polyangiitis [GPA], n=6) died during follow-up. SF-36 PCS was significantly but weakly associated with Birmingham Vasculitis Activity Score, Five-factor score, erythrocyte sedimentation rate (ESR), and C-reactive protein. However, SF-36 MCS was not associated with ESR. In the multivariable Cox analysis, a decrease of SF-36 PCS score by one unit indicated a higher death risk (hazard ratio [HR]: 1.030; 95% confidence interval [CI]: 1.007, 1.052; p=0.041), which was not for SF-36 MCS. IPTW analysis in a subgroup of MPA and GPA patients revealed increased patient mortality with SF-36 PCS <53.75 independently (HR: 3.249; 95% CI: 1.169, 9.033; p=0.024). Conclusion: Poor baseline physical functioning associated with premature death in patients with MPA and GPA. HRQoL assessment during initial diagnosis may provide clinical insights for this population. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | W.B. Saunders | - |
dc.relation.isPartOf | SEMINARS IN ARTHRITIS AND RHEUMATISM | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis* / diagnosis | - |
dc.subject.MESH | Antibodies, Antineutrophil Cytoplasmic | - |
dc.subject.MESH | Granulomatosis with Polyangiitis* / diagnosis | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Microscopic Polyangiitis* | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Quality of Life | - |
dc.title | Clinical association of health-related quality of life and mortality in an antineutrophil cytoplasmic antibody-associated vasculitis cohort | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Sung Soo Ahn | - |
dc.contributor.googleauthor | Seok-Jae Heo | - |
dc.contributor.googleauthor | Jang Woo Ha | - |
dc.contributor.googleauthor | Yong-Beom Park | - |
dc.contributor.googleauthor | Sang-Won Lee | - |
dc.identifier.doi | 10.1016/j.semarthrit.2023.152353 | - |
dc.contributor.localId | A01579 | - |
dc.contributor.localId | A02233 | - |
dc.contributor.localId | A02824 | - |
dc.relation.journalcode | J02649 | - |
dc.identifier.eissn | 1532-866X | - |
dc.identifier.pmid | 38128176 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0049017223001956 | - |
dc.subject.keyword | Health-related quality of life | - |
dc.subject.keyword | SF-36 | - |
dc.subject.keyword | antineutrophil cytoplasmic antibody | - |
dc.subject.keyword | mortality | - |
dc.subject.keyword | vasculitis | - |
dc.contributor.alternativeName | Park, Yong Beom | - |
dc.contributor.affiliatedAuthor | 박용범 | - |
dc.contributor.affiliatedAuthor | 안성수 | - |
dc.contributor.affiliatedAuthor | 이상원 | - |
dc.citation.volume | 64 | - |
dc.citation.startPage | 152353 | - |
dc.identifier.bibliographicCitation | SEMINARS IN ARTHRITIS AND RHEUMATISM, Vol.64 : 152353, 2024-02 | - |
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