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Patients with systemic lupus erythematosus who are underweight have distinct disease characteristics
DC Field | Value | Language |
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dc.contributor.author | 권오찬 | - |
dc.contributor.author | 박민찬 | - |
dc.date.accessioned | 2024-03-22T06:25:50Z | - |
dc.date.available | 2024-03-22T06:25:50Z | - |
dc.date.issued | 2024-01 | - |
dc.identifier.issn | 0961-2033 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/198545 | - |
dc.description.abstract | Objective: This study aimed to detail the disease characteristics of systemic lupus erythematosus (SLE) in individuals who are underweight and assess whether underweight status is associated with SLE disease activity. Methods: This was a retrospective cohort study involving 218 patients newly diagnosed with SLE. Patients were categorized as underweight (body mass index [BMI] <18.5 kg/m2) or not underweight (BMI ≥18.5 kg/m2). We reviewed disease characteristics including the SLE Disease Activity Index 2000 (SLEDAI-2K) at diagnosis. High disease activity was defined as SLEDAI-2K ≥10. Disease characteristics were compared between those who were underweight and not underweight. We used multivariable logistic regression analysis to determine whether underweight status is associated with high disease activity. Results: Out of the 218 patients, 35 (16.1%) were underweight and 183 (83.9%) were not. Underweight patients had less renal involvement (5.7% vs 20.2%, p = .040), lower C-reactive protein levels (1.0 [0.3-2.3] mg/L vs 1.2 [0.8-5.0] mg/L, p = .028), and lower SLEDAI-2K scores (6.7 ± 4.6 vs 9.1 ± 5.7, p = .009), and were less likely to be at high disease activity status (22.9% vs 42.6%, p = .028), compared with those who were not underweight. Following adjustment for multiple covariates, being underweight was inversely associated with high disease activity status (adjusted odds ratio = 0.38, 95% confidence interval = 0.16 to 0.92, p = .031). Conclusion: Patients with SLE who were underweight showed less renal involvement and lower SLEDAI-2K scores compared with those who were not underweight. Moreover, those with SLE who were underweight had a 60% lower risk of exhibiting high disease activity. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | SAGE Publications | - |
dc.relation.isPartOf | LUPUS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lupus Erythematosus, Systemic* / complications | - |
dc.subject.MESH | Lupus Erythematosus, Systemic* / diagnosis | - |
dc.subject.MESH | Lupus Erythematosus, Systemic* / epidemiology | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Severity of Illness Index | - |
dc.subject.MESH | Thinness / epidemiology | - |
dc.title | Patients with systemic lupus erythematosus who are underweight have distinct disease characteristics | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Oh Chan Kwon | - |
dc.contributor.googleauthor | Min-Chan Park | - |
dc.identifier.doi | 10.1177/09612033231220726 | - |
dc.contributor.localId | A05818 | - |
dc.contributor.localId | A01470 | - |
dc.relation.journalcode | J02175 | - |
dc.identifier.eissn | 1477-0962 | - |
dc.identifier.pmid | 38050807 | - |
dc.identifier.url | https://journals.sagepub.com/doi/10.1177/09612033231220726 | - |
dc.subject.keyword | Systemic lupus erythematosus | - |
dc.subject.keyword | disease activity | - |
dc.subject.keyword | underweight | - |
dc.contributor.alternativeName | Kwon, Oh Chan | - |
dc.contributor.affiliatedAuthor | 권오찬 | - |
dc.contributor.affiliatedAuthor | 박민찬 | - |
dc.citation.volume | 33 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 68 | - |
dc.citation.endPage | 74 | - |
dc.identifier.bibliographicCitation | LUPUS, Vol.33(1) : 68-74, 2024-01 | - |
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