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Sex Differences in Midterm Prognostic Implications of High Platelet Reactivity After Percutaneous Coronary Intervention With Drug-Eluting Stents in East Asian Patients: Results From the PTRG-DES (Platelet Function and Genotype-Related Long-Term Prognosis in Drug-Eluting Stent-Treated Patients With Coronary Artery Disease) Consortium
DC Field | Value | Language |
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dc.contributor.author | 김병극 | - |
dc.date.accessioned | 2024-03-22T06:14:06Z | - |
dc.date.available | 2024-03-22T06:14:06Z | - |
dc.date.issued | 2023-05 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/198469 | - |
dc.description.abstract | Background Although high platelet reactivity (HPR) on clopidogrel is associated with higher ischemic events and lower bleeding events in patients who have undergone percutaneous coronary intervention with drug-eluting stents, the differential risk of HPR in East Asian women versus men is unknown. Methods and Results We compared 11 714 patients enrolled in the PTRG-DES (Platelet Function and Genotype-Related Long-Term Prognosis in Drug-Eluting Stent-Treated Patients With Coronary Artery Disease) Consortium according to sex and the presence/absence of HPR on clopidogrel (defined as ≥252 P2Y12 reactivity units). The primary study end point was major adverse cardiac and cerebrovascular events (MACCEs; comprising all-cause mortality, myocardial infarction, cerebrovascular accident, and stent thrombosis). HPR was more common in women (46.7%) than in men (28.1%). In propensity-adjusted models, HPR was an independent predictor of MACCEs (men with HPR: hazard ratio [HR], 1.60 [95% CI, 1.20-2.12]; women with HPR: HR, 0.99 [95% CI, 0.69-1.42]) and all-cause mortality (men with HPR: HR, 1.61 [95% CI, 1.07-2.44]; women with HPR: HR, 0.92 [95% CI, 0.57-1.50]) in men, although those associations were insignificant among women. In addition, a significant interaction between sex was noted in the associations between HPR and MACCE (Pinteraction=0.013) or all-cause mortality (Pinteraction=0.025). Conclusions In this study, HPR was a differential risk factor for 1-year MACCEs and all-cause mortality in women and men. And it was an independent predictor of 1-year MACCEs and all-cause mortality in men but not in women. Registration URL: https://www.clinicaltrials.gov; Unique identifier: NCT04734028. Registered July 9, 2003, https://clinicaltrials.gov/ct2/show/NCT04734028. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Wiley-Blackwell | - |
dc.relation.isPartOf | JOURNAL OF THE AMERICAN HEART ASSOCIATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Blood Platelets / drug effects | - |
dc.subject.MESH | Blood Platelets / physiology | - |
dc.subject.MESH | Clopidogrel / pharmacology | - |
dc.subject.MESH | Clopidogrel / therapeutic use | - |
dc.subject.MESH | Coronary Artery Disease* / complications | - |
dc.subject.MESH | Coronary Artery Disease* / mortality | - |
dc.subject.MESH | Coronary Artery Disease* / therapy | - |
dc.subject.MESH | Drug-Eluting Stents* | - |
dc.subject.MESH | East Asian People* / statistics & numerical data | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Percutaneous Coronary Intervention* / adverse effects | - |
dc.subject.MESH | Percutaneous Coronary Intervention* / instrumentation | - |
dc.subject.MESH | Percutaneous Coronary Intervention* / methods | - |
dc.subject.MESH | Percutaneous Coronary Intervention* / mortality | - |
dc.subject.MESH | Platelet Aggregation Inhibitors / pharmacology | - |
dc.subject.MESH | Platelet Aggregation Inhibitors / therapeutic use | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Sex Factors | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Sex Differences in Midterm Prognostic Implications of High Platelet Reactivity After Percutaneous Coronary Intervention With Drug-Eluting Stents in East Asian Patients: Results From the PTRG-DES (Platelet Function and Genotype-Related Long-Term Prognosis in Drug-Eluting Stent-Treated Patients With Coronary Artery Disease) Consortium | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Soo-Jin Kim | - |
dc.contributor.googleauthor | Ae-Young Her | - |
dc.contributor.googleauthor | Young-Hoon Jeong | - |
dc.contributor.googleauthor | Byeong-Keuk Kim | - |
dc.contributor.googleauthor | Hyung Joon Joo | - |
dc.contributor.googleauthor | Yongwhi Park | - |
dc.contributor.googleauthor | Kiyuk Chang | - |
dc.contributor.googleauthor | Young Bin Song | - |
dc.contributor.googleauthor | Sung Gyun Ahn | - |
dc.contributor.googleauthor | Jung-Won Suh | - |
dc.contributor.googleauthor | Sang Yeub Lee | - |
dc.contributor.googleauthor | Jung Rae Cho | - |
dc.contributor.googleauthor | Hyo-Soo Kim | - |
dc.contributor.googleauthor | Moo Hyun Kim | - |
dc.contributor.googleauthor | Do-Sun Lim | - |
dc.contributor.googleauthor | Eun-Seok Shin | - |
dc.contributor.googleauthor | PTRG‐DES Consortium Investigators | - |
dc.identifier.doi | 10.1161/JAHA.122.027804 | - |
dc.contributor.localId | A00493 | - |
dc.relation.journalcode | J01774 | - |
dc.identifier.eissn | 2047-9980 | - |
dc.identifier.pmid | 37119080 | - |
dc.subject.keyword | coronary artery disease | - |
dc.subject.keyword | drug‐eluting stent | - |
dc.subject.keyword | female | - |
dc.subject.keyword | platelet function | - |
dc.subject.keyword | sex | - |
dc.contributor.alternativeName | Kim, Byeong Keuk | - |
dc.contributor.affiliatedAuthor | 김병극 | - |
dc.citation.volume | 12 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | e027804 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN HEART ASSOCIATION, Vol.12(9) : e027804, 2023-05 | - |
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