Cited 1 times in
Olfactory marker protein regulates adipogenesis via the cAMP-IκBα pathway
DC Field | Value | Language |
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dc.contributor.author | 이은직 | - |
dc.contributor.author | 오주헌 | - |
dc.contributor.author | 강찬우 | - |
dc.contributor.author | 구철룡 | - |
dc.contributor.author | 조윤희 | - |
dc.date.accessioned | 2024-03-22T06:05:47Z | - |
dc.date.available | 2024-03-22T06:05:47Z | - |
dc.date.issued | 2023-09 | - |
dc.identifier.issn | 0303-7207 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/198391 | - |
dc.description.abstract | Olfactory marker protein (OMP) regulates olfactory transduction and is also expressed in adipose tissue. Since it serves as a regulatory buffer for cyclic AMP (cAMP) levels, we hypothesized that it plays a role in modulating adipocyte differentiation. To determine the role of OMP in adipogenesis, we examined the differences in body weight, adipose tissue mass, and adipogenic or thermogenic gene expression between high-fat diet-fed control and Omp-knockout (KO) mice. cAMP production, adipogenic gene expression, and cAMP response element binding protein (CREB) phosphorylation were measured during the differentiation of 3T3-L1 preadipocytes and mouse embryonic fibroblasts (MEFs). RNA sequencing was performed to determine the gene expression patterns responsible for the reduction in adipogenesis when Omp was deleted. Body weight, adipose tissue mass, and adipocyte size decreased in Omp-KO mice. Furthermore, cAMP production and CREB phosphorylation reduced during adipogenesis induced in Omp−/− MEFs, and the Nuclear factor kappa B was activated due to significantly reduced expression of its inhibitor. Collectively, our results suggest that loss of OMP function inhibits adipogenesis by affecting adipocyte differentiation. © 2023 The Authors | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | North Holland Publishing | - |
dc.relation.isPartOf | MOLECULAR AND CELLULAR ENDOCRINOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | 3T3-L1 Cells | - |
dc.subject.MESH | Adipogenesis* / genetics | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Body Weight | - |
dc.subject.MESH | Cell Differentiation | - |
dc.subject.MESH | Cyclic AMP* | - |
dc.subject.MESH | Fibroblasts | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | NF-KappaB Inhibitor alpha | - |
dc.subject.MESH | Olfactory Marker Protein | - |
dc.title | Olfactory marker protein regulates adipogenesis via the cAMP-IκBα pathway | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Yaru Bao | - |
dc.contributor.googleauthor | Ju Hun Oh | - |
dc.contributor.googleauthor | Chan Woo Kang | - |
dc.contributor.googleauthor | Cheol Ryong Ku | - |
dc.contributor.googleauthor | Yoon Hee Cho | - |
dc.contributor.googleauthor | Eun Jig Lee | - |
dc.identifier.doi | 10.1016/j.mce.2023.111992 | - |
dc.contributor.localId | A03050 | - |
dc.relation.journalcode | J02244 | - |
dc.identifier.eissn | 1872-8057 | - |
dc.identifier.pmid | 37328092 | - |
dc.subject.keyword | Adipogenesis | - |
dc.subject.keyword | Adipose tissue | - |
dc.subject.keyword | NF-κB | - |
dc.subject.keyword | Olfactory marker protein | - |
dc.subject.keyword | cAMP | - |
dc.contributor.alternativeName | Lee, Eun Jig | - |
dc.contributor.affiliatedAuthor | 이은직 | - |
dc.citation.volume | 575 | - |
dc.citation.startPage | 111992 | - |
dc.identifier.bibliographicCitation | MOLECULAR AND CELLULAR ENDOCRINOLOGY, Vol.575 : 111992, 2023-09 | - |
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